FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1242720003> ?p ?o ?g. }

• W1242720003 endingPage "943" @default.
• W1242720003 startingPage "938" @default.
• W1242720003 abstract "Benzodiazepines are among the most frequently prescribed medicines for anxiety disorders and are present in many toxicological screens. These drugs are often administered in the commission of drug facilitated sexual assaults due their effects on the central nervous system. Due to the potency of the drugs, only small amounts are usually given to victims; therefore, the target detection limit for these compounds in biological samples has been set at 50 ng/mL. Currently the standard screening method for detection of this class of drug is the immunoassay; however, screening methods that are more sensitive and selective than immunoassays are needed to encompass the wide range of structural variants of this class of compounds. Surface enhanced Raman spectroscopy (SERS) can be highly sensitive and has been shown to permit analysis of various benzodiazepines with limits of detection as low as 6 ng/mL. This technique permits analytical results in less than 2 min when used on pure drug samples. For biological samples, a key issue for analysis by SERS is removal of exogenous salts and matrix components. In this paper we examine supported liquid extraction as a useful preparation technique for SERS detection. Supported liquid extraction has many of the benefits of liquid-liquid extraction along with the ability to be automated. This technique provides a fast and clean extraction for benzodiazepines from urine at a pH of 5.0, and does not produce large quantities of solvent waste. To validate this procedure we have determined figures of merit and examined simulated urine samples prepared with commonly appearing interferences. It was shown that at a pH 5.0 many drugs that are prevalent in urine samples can be removed, permitting a selective detection of the benzodiazepine of interest. This technique has been shown to provide rapid (less than 20 min), sensitive, and specific detection of benzodiazepines with limits of detection between 32 and 600 ng/mL and dynamic range of 32-25,000 ng/mL. It provides the forensic community with a sensitive and specific screening technique for the detection of benzodiazepines in drug facilitated assault cases." @default.
• W1242720003 created "2016-06-24" @default.
• W1242720003 creator A5076387928 @default.
• W1242720003 creator A5079048744 @default.
• W1242720003 date "2015-11-01" @default.
• W1242720003 modified "2023-10-02" @default.
• W1242720003 title "The application of supported liquid extraction in the analysis of benzodiazepines using surface enhanced Raman spectroscopy" @default.
• W1242720003 cites W1576374727 @default.
• W1242720003 cites W1879320329 @default.
• W1242720003 cites W1972156507 @default.
• W1242720003 cites W1998750508 @default.
• W1242720003 cites W1999062969 @default.
• W1242720003 cites W2020256059 @default.
• W1242720003 cites W2046317435 @default.
• W1242720003 cites W2048702423 @default.
• W1242720003 cites W2049058466 @default.
• W1242720003 cites W2049554798 @default.
• W1242720003 cites W2064140340 @default.
• W1242720003 cites W2073258130 @default.
• W1242720003 cites W2079312025 @default.
• W1242720003 cites W2088773120 @default.
• W1242720003 cites W2095962981 @default.
• W1242720003 cites W2101607365 @default.
• W1242720003 cites W2112820102 @default.
• W1242720003 cites W2116816486 @default.
• W1242720003 cites W2134678924 @default.
• W1242720003 cites W2144883595 @default.
• W1242720003 cites W2155776931 @default.
• W1242720003 cites W2161504208 @default.
• W1242720003 cites W2168963572 @default.
• W1242720003 doi "https://doi.org/10.1016/j.talanta.2015.07.036" @default.
• W1242720003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26452911" @default.
• W1242720003 hasPublicationYear "2015" @default.
• W1242720003 type Work @default.
• W1242720003 sameAs 1242720003 @default.
• W1242720003 citedByCount "26" @default.
• W1242720003 countsByYear W12427200032016 @default.
• W1242720003 countsByYear W12427200032017 @default.
• W1242720003 countsByYear W12427200032018 @default.
• W1242720003 countsByYear W12427200032019 @default.
• W1242720003 countsByYear W12427200032020 @default.
• W1242720003 countsByYear W12427200032021 @default.
• W1242720003 countsByYear W12427200032022 @default.
• W1242720003 countsByYear W12427200032023 @default.
• W1242720003 crossrefType "journal-article" @default.
• W1242720003 hasAuthorship W1242720003A5076387928 @default.
• W1242720003 hasAuthorship W1242720003A5079048744 @default.
• W1242720003 hasConcept C119128265 @default.
• W1242720003 hasConcept C120665830 @default.
• W1242720003 hasConcept C121332964 @default.
• W1242720003 hasConcept C169573571 @default.
• W1242720003 hasConcept C178790620 @default.
• W1242720003 hasConcept C185592680 @default.
• W1242720003 hasConcept C2777790068 @default.
• W1242720003 hasConcept C2780026642 @default.
• W1242720003 hasConcept C2780471494 @default.
• W1242720003 hasConcept C40003534 @default.
• W1242720003 hasConcept C43617362 @default.
• W1242720003 hasConcept C4725764 @default.
• W1242720003 hasConcept C55493867 @default.
• W1242720003 hasConceptScore W1242720003C119128265 @default.
• W1242720003 hasConceptScore W1242720003C120665830 @default.
• W1242720003 hasConceptScore W1242720003C121332964 @default.
• W1242720003 hasConceptScore W1242720003C169573571 @default.
• W1242720003 hasConceptScore W1242720003C178790620 @default.
• W1242720003 hasConceptScore W1242720003C185592680 @default.
• W1242720003 hasConceptScore W1242720003C2777790068 @default.
• W1242720003 hasConceptScore W1242720003C2780026642 @default.
• W1242720003 hasConceptScore W1242720003C2780471494 @default.
• W1242720003 hasConceptScore W1242720003C40003534 @default.
• W1242720003 hasConceptScore W1242720003C43617362 @default.
• W1242720003 hasConceptScore W1242720003C4725764 @default.
• W1242720003 hasConceptScore W1242720003C55493867 @default.
• W1242720003 hasLocation W12427200031 @default.
• W1242720003 hasLocation W12427200032 @default.
• W1242720003 hasOpenAccess W1242720003 @default.
• W1242720003 hasPrimaryLocation W12427200031 @default.
• W1242720003 hasRelatedWork W1980714464 @default.
• W1242720003 hasRelatedWork W1988317878 @default.
• W1242720003 hasRelatedWork W1993409185 @default.
• W1242720003 hasRelatedWork W2017325659 @default.
• W1242720003 hasRelatedWork W2017447325 @default.
• W1242720003 hasRelatedWork W2023342487 @default.
• W1242720003 hasRelatedWork W2033364217 @default.
• W1242720003 hasRelatedWork W2047901235 @default.
• W1242720003 hasRelatedWork W2061879738 @default.
• W1242720003 hasRelatedWork W2130473357 @default.
• W1242720003 hasVolume "144" @default.
• W1242720003 isParatext "false" @default.
• W1242720003 isRetracted "false" @default.
• W1242720003 magId "1242720003" @default.
• W1242720003 workType "article" @default.