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- W12427735 abstract "This chapter summarizes the changes in parathyroid function with aging. Parathyroid hormone (PTH) serum concentrations clearly increase with age in a parallel manner in women and in men. At a functional and anatomic level, this is because of some degree of parathyroid hyperplasia in elderly persons. Indirect and direct evidence implicates the age-related increase in serum PTH in mediating at least part of the age-related increase in bone turnover and bone loss. If bone resorption is more dependent on serum PTH in the elderly compared to the young women, then the decrease in bone resorption markers following suppression of PTH secretion by an intravenous calcium infusion should be greater in the elderly women. Though vitamin D deficiency and impaired renal1α-hydroxylase activity resulting in deficient 1, 25 dihydroxyvitamin 2 D production may contribute to the secondary hyperparathyroidism in some elderly individuals, age-associated changes in calcium homeostasis, related to long-term sequelae of sex steroid deficiency, are a major cause of the secondary hyperparathyroidism of aging." @default.
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- W12427735 date "2001-01-01" @default.
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- W12427735 title "Parathyroid Function in the Normal Aging Process" @default.
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- W12427735 doi "https://doi.org/10.1016/b978-012098651-4/50055-9" @default.
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