Matches in SemOpenAlex for { <https://semopenalex.org/work/W124369320> ?p ?o ?g. }
- W124369320 abstract "DNA topoisomerases are important nuclear enzymes involved in many aspects of DNA metabolism, such as DNA replication, RNA transcription, chromosome condensation, and segregation (1, 2, 3, 4, 5). They perform their topological transformation reactions on DNA via a concerted breakage/religation mechanism (4,6, 7, 8). Because of their delicate act on DNA, topoisomerases can be double-edged swords. It is now well established that many xenobiotics, DNA lesions, and physiological stresses (e.g., oxidative stress, acidic pH stress, thiol stress) can interfere with the breakage/religation reactions of topoisomerases, resulting in topoisomerase-mediated DNA damage (9, 10, 11, 12, 13, 14). Among the five human DNA topoisomerases (hTOP1, hTOP2α, hTOP2β, hTOP3α, and hTOP3β), the first three have been identified to be molecular targets of anticancer drugs (1,9,11,15, 16, 17, 18, 19, 20, 21, 22)." @default.
- W124369320 created "2016-06-24" @default.
- W124369320 creator A5003747504 @default.
- W124369320 creator A5057145998 @default.
- W124369320 date "2005-01-01" @default.
- W124369320 modified "2023-09-27" @default.
- W124369320 title "Mechanism of Action of Topoisomerase 1 Poisons" @default.
- W124369320 cites W1267625934 @default.
- W124369320 cites W134474111 @default.
- W124369320 cites W1482083885 @default.
- W124369320 cites W1486866108 @default.
- W124369320 cites W1508099272 @default.
- W124369320 cites W1515980537 @default.
- W124369320 cites W1517778647 @default.
- W124369320 cites W1536538430 @default.
- W124369320 cites W1545435534 @default.
- W124369320 cites W1549846058 @default.
- W124369320 cites W1579921798 @default.
- W124369320 cites W1581042042 @default.
- W124369320 cites W1604739675 @default.
- W124369320 cites W1618390676 @default.
- W124369320 cites W1639589518 @default.
- W124369320 cites W1666755687 @default.
- W124369320 cites W1676414257 @default.
- W124369320 cites W1705636341 @default.
- W124369320 cites W1760694280 @default.
- W124369320 cites W1841552349 @default.
- W124369320 cites W1871475547 @default.
- W124369320 cites W1904178031 @default.
- W124369320 cites W1906310597 @default.
- W124369320 cites W1957191667 @default.
- W124369320 cites W1963658914 @default.
- W124369320 cites W1966263533 @default.
- W124369320 cites W1966761762 @default.
- W124369320 cites W1967020705 @default.
- W124369320 cites W1969309856 @default.
- W124369320 cites W1970061483 @default.
- W124369320 cites W1970869950 @default.
- W124369320 cites W1972166544 @default.
- W124369320 cites W1972222329 @default.
- W124369320 cites W1972814141 @default.
- W124369320 cites W1973255116 @default.
- W124369320 cites W1975426967 @default.
- W124369320 cites W1976931280 @default.
- W124369320 cites W1980868679 @default.
- W124369320 cites W1984243651 @default.
- W124369320 cites W1985426723 @default.
- W124369320 cites W1988516897 @default.
- W124369320 cites W1989961298 @default.
- W124369320 cites W1990863304 @default.
- W124369320 cites W1993376568 @default.
- W124369320 cites W1994135840 @default.
- W124369320 cites W1996783278 @default.
- W124369320 cites W1997757896 @default.
- W124369320 cites W1999054610 @default.
- W124369320 cites W1999902563 @default.
- W124369320 cites W2000372287 @default.
- W124369320 cites W200286807 @default.
- W124369320 cites W2004070915 @default.
- W124369320 cites W2004214053 @default.
- W124369320 cites W2004722555 @default.
- W124369320 cites W2009856824 @default.
- W124369320 cites W2009885625 @default.
- W124369320 cites W2010999235 @default.
- W124369320 cites W2011088503 @default.
- W124369320 cites W2012100191 @default.
- W124369320 cites W2012734297 @default.
- W124369320 cites W2016675662 @default.
- W124369320 cites W2017185151 @default.
- W124369320 cites W2017742066 @default.
- W124369320 cites W2018185888 @default.
- W124369320 cites W2018460264 @default.
- W124369320 cites W2018770864 @default.
- W124369320 cites W2019020165 @default.
- W124369320 cites W2019897388 @default.
- W124369320 cites W2021325933 @default.
- W124369320 cites W2023697509 @default.
- W124369320 cites W2024135682 @default.
- W124369320 cites W2024935012 @default.
- W124369320 cites W2025523092 @default.
- W124369320 cites W2026637165 @default.
- W124369320 cites W2027095809 @default.
- W124369320 cites W2028375591 @default.
- W124369320 cites W2031733136 @default.
- W124369320 cites W2034250689 @default.
- W124369320 cites W2035074423 @default.
- W124369320 cites W2035079536 @default.
- W124369320 cites W2035174696 @default.
- W124369320 cites W2035948254 @default.
- W124369320 cites W2035966657 @default.
- W124369320 cites W2037670899 @default.
- W124369320 cites W2037845650 @default.
- W124369320 cites W2037902796 @default.
- W124369320 cites W2038384113 @default.
- W124369320 cites W2039274715 @default.
- W124369320 cites W2039953129 @default.
- W124369320 cites W2040955353 @default.
- W124369320 cites W2041642148 @default.
- W124369320 cites W2041968244 @default.
- W124369320 cites W2046037983 @default.