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- W124413238 abstract "Several studies have demonstrated an association of particulate matter (PM) exposure and cardiovascular (CV) complications. However, the mechanisms of PM-induced CV complications are not clear. Because coarse PM is often associated with lipopolysaccharide (LPS), we investigated if coarse PM (≤10 μm mean aerodynamic diameter) combined with LPS would induce pulmonary and systemic inflammation. C57BL/6J mice were intratracheally instilled with 100μl of saline, PM (200μg), LPS (100μg), or PM+LPS. Eighteen hours later, pulmonary and systemic inflammation were assessed by the measurement of proinflammatory cytokines TNF-α and IL-6 in lung homogenate and plasma. We found that pulmonary TNF-α and IL-6 were significantly different among the PM, LPS, and PM+LPS groups, where the latter group had the greatest concentration. There were no differences in plasma TNF-α among the groups. However, plasma IL-6 was significantly greater in the PM+LPS group, but not in the LPS group, compared to the PM group. Our results demonstrate that the PM+LPS group elicited the greatest response in pulmonary and systemic inflammation. These findings indicate that the combination of coarse PM and LPS causes a systemic inflammatory response which may aggravate the CV complications of air pollution. Funded by a grant from the Arizona Biomedical Research Commission and NIH ES 06694" @default.
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- W124413238 date "2007-01-01" @default.
- W124413238 modified "2023-09-24" @default.
- W124413238 title "The Instillation of Coarse Coal Ash Particulate Matter Combined with Lipopolysaccharide Causes Both Pulmonary and Systemic Inflammation" @default.
- W124413238 doi "https://doi.org/10.1096/fasebj.21.6.a1139-c" @default.
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