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- W1244236496 abstract "The prevalence of type 2 diabetes mellitus (T2DM) is increasing, and it affects 338 million people worldwide. Approximately 36 million people worldwide have dementia. Alzheimer’s disease (AD) is the most common form of dementia in elderly people. There is convincing evidence from epidemiology, neuropathology and neuroimaging showing an increased risk of AD in people with T2DM. The possible mechanisms linking T2DM and AD include vascular pathways, hyperglycemia, insulin resistance, inflammation, oxidative stress, and mitochondrial dysfunction as well as genetic factors. T2DM may lead to AD through a mixed pathology invoving both vascual and nonvascular changes in the brain. Among diabetic patients, diabetic treatment may play an imprtant role in the development of AD, and effective glyceamic control may attenuate the risk of AD, while hypoglycemia may increase the risk of dementia. Although T2DM and AD may share common pathological process, the two disorders may not be directly linked. A better understanding of the key mechanisms underlying diabetes and AD is needed for the design of preventive and therapeutic strategies." @default.
- W1244236496 created "2016-06-24" @default.
- W1244236496 creator A5024473114 @default.
- W1244236496 date "2013-01-01" @default.
- W1244236496 modified "2023-10-02" @default.
- W1244236496 title "Diabetes Mellitus and Its Impact on Sporadic Alzheimer’s Disease" @default.
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- W1244236496 doi "https://doi.org/10.1007/978-1-62703-598-9_12" @default.
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