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- W1244946472 abstract "Organisms have developed metal regulatory mechanisms in response to changes in the bioavailability of trace metals. Just as metal bioavailability dictates cellular uptake, intracellular metal speciation determines the availability of metals to exert biological effects. However, the missing link in understanding the relationship between metal uptake and biological responses is the ability to accurately measure intracellular metal speciation. We conducted Pb exposure studies on the well-characterized model green alga Chlamydomonas reinhardtii and identified temporal changes in intracellular Pb speciation under conditions relevant for fresh water ecosystems using resonant X-ray emission spectroscopy (RXES), which possesses enhanced sensitivity to functional group chemistry relative to X-ray absorption spectroscopy (XAS). Analysis of RXES maps show that only a small fraction of total intracellular Pb was complexed by thiol groups. Initial sequestration of Pb in oxides and inorganic phosphate was followed by binding of Pb to organic phosphate, suggesting potential interference in vital cellular functions. These results contrast proposed detoxification responses involving complexation by thiol groups from peptides." @default.
- W1244946472 created "2016-06-24" @default.
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- W1244946472 date "2015-08-31" @default.
- W1244946472 modified "2023-09-26" @default.
- W1244946472 title "Tracking the Temporal Dynamics of Intracellular Lead Speciation in a Green Alga" @default.
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- W1244946472 doi "https://doi.org/10.1021/acs.est.5b02603" @default.
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