Matches in SemOpenAlex for { <https://semopenalex.org/work/W1245179976> ?p ?o ?g. }
- W1245179976 endingPage "1363" @default.
- W1245179976 startingPage "1353" @default.
- W1245179976 abstract "The aim of this study is to investigate the clinicopathologic significance and potential role of metastasis-associated in colon cancer-1 (MACC1) in the progression of cervical cancer.MACC1 expression was examined in cervical cancer cell lines, 6 matched cervical cancer tissues, and adjacent noncancerous tissues using Western blotting and real-time reverse transcriptase polymerase chain reaction. MACC1 protein expression and localization were determined in 181 paraffin-embedded archived cervical cancer samples using immunohistochemistry. Statistical analyses were applied to evaluate the clinicopathologic significance. The effects of MACC1 on cell migration, invasion, and angiogenesis were examined using migration assay, wound healing assay, 3-dimensional morphogenesis assay, and chicken chorioallantoic membrane assay. Western blotting was performed to examine the impact of MACC1 on the Akt and nuclear factor κB signaling pathways.Both protein and messenger RNA levels of MACC1 was up-regulated in cervical cancer cell lines and cervical cancer tissues, as compared with normal tissues. High MACC1 expression was detected in 96 (53%) of 181 of the cervical cancer tissues. In addition, high MACC1 expression correlated significantly with aggressiveness of cervical cancer, including International Federation of Gynecology and Obstetric stage (P = 0.001), pelvic lymph node metastasis (P = 0.004), recurrence (P = 0.037), and poor survival (P = 0.001). Moreover, enforced expression of MACC1 in cervical cancer cell lines significantly enhanced cell migration, invasion, and angiogenesis. Conversely, knockdown of MACC1 caused an inhibition of cell migration, invasion, and angiogenesis. Up-regulation of MACC1 increased, but knockdown of MACC1 decreased the expression of matrix metalloproteinase-2 and matrix metalloproteinase-9. Furthermore, enforced expression of MACC1 could enhance, but knockdown of MACC1 could reduce AKT and nuclear factor κB pathway activity.Our findings suggest that MACC1 protein, as a valuable marker of cervical cancer prognosis, plays an important role in the progression of human cervical cancer cells." @default.
- W1245179976 created "2016-06-24" @default.
- W1245179976 creator A5008463865 @default.
- W1245179976 creator A5012764240 @default.
- W1245179976 creator A5013125876 @default.
- W1245179976 creator A5023794166 @default.
- W1245179976 creator A5029727977 @default.
- W1245179976 creator A5038002338 @default.
- W1245179976 creator A5040868085 @default.
- W1245179976 creator A5054235033 @default.
- W1245179976 creator A5086645676 @default.
- W1245179976 date "2015-10-01" @default.
- W1245179976 modified "2023-09-27" @default.
- W1245179976 title "Metastasis-Associated in Colon Cancer-1 Associates With Poor Prognosis and Promotes Cell Invasion and Angiogenesis in Human Cervical Cancer" @default.
- W1245179976 cites W1532283611 @default.
- W1245179976 cites W1578704981 @default.
- W1245179976 cites W1581923494 @default.
- W1245179976 cites W1737632190 @default.
- W1245179976 cites W1906871174 @default.
- W1245179976 cites W1934485925 @default.
- W1245179976 cites W1982575342 @default.
- W1245179976 cites W1983074899 @default.
- W1245179976 cites W1986834336 @default.
- W1245179976 cites W2002490063 @default.
- W1245179976 cites W2006208922 @default.
- W1245179976 cites W2008001403 @default.
- W1245179976 cites W2013181810 @default.
- W1245179976 cites W2019994604 @default.
- W1245179976 cites W2026726511 @default.
- W1245179976 cites W2031431198 @default.
- W1245179976 cites W2036460370 @default.
- W1245179976 cites W2049400611 @default.
- W1245179976 cites W2051994734 @default.
- W1245179976 cites W2059937333 @default.
- W1245179976 cites W2076604472 @default.
- W1245179976 cites W2093390427 @default.
- W1245179976 cites W2094391933 @default.
- W1245179976 cites W2095143857 @default.
- W1245179976 cites W2096886845 @default.
- W1245179976 cites W2097211573 @default.
- W1245179976 cites W2100910477 @default.
- W1245179976 cites W2101976544 @default.
- W1245179976 cites W2104236657 @default.
- W1245179976 cites W2105365694 @default.
- W1245179976 cites W2114014236 @default.
- W1245179976 cites W2115007325 @default.
- W1245179976 cites W2118590850 @default.
- W1245179976 cites W2136390065 @default.
- W1245179976 cites W2137571589 @default.
- W1245179976 cites W2139906829 @default.
- W1245179976 cites W2146278165 @default.
- W1245179976 cites W2149784811 @default.
- W1245179976 cites W2151773547 @default.
- W1245179976 cites W2157932672 @default.
- W1245179976 cites W2157947752 @default.
- W1245179976 cites W2164977381 @default.
- W1245179976 cites W2170579655 @default.
- W1245179976 cites W2314663284 @default.
- W1245179976 doi "https://doi.org/10.1097/igc.0000000000000524" @default.
- W1245179976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5106080" @default.
- W1245179976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26332389" @default.
- W1245179976 hasPublicationYear "2015" @default.
- W1245179976 type Work @default.
- W1245179976 sameAs 1245179976 @default.
- W1245179976 citedByCount "24" @default.
- W1245179976 countsByYear W12451799762016 @default.
- W1245179976 countsByYear W12451799762017 @default.
- W1245179976 countsByYear W12451799762018 @default.
- W1245179976 countsByYear W12451799762019 @default.
- W1245179976 countsByYear W12451799762020 @default.
- W1245179976 countsByYear W12451799762021 @default.
- W1245179976 countsByYear W12451799762022 @default.
- W1245179976 countsByYear W12451799762023 @default.
- W1245179976 crossrefType "journal-article" @default.
- W1245179976 hasAuthorship W1245179976A5008463865 @default.
- W1245179976 hasAuthorship W1245179976A5012764240 @default.
- W1245179976 hasAuthorship W1245179976A5013125876 @default.
- W1245179976 hasAuthorship W1245179976A5023794166 @default.
- W1245179976 hasAuthorship W1245179976A5029727977 @default.
- W1245179976 hasAuthorship W1245179976A5038002338 @default.
- W1245179976 hasAuthorship W1245179976A5040868085 @default.
- W1245179976 hasAuthorship W1245179976A5054235033 @default.
- W1245179976 hasAuthorship W1245179976A5086645676 @default.
- W1245179976 hasBestOaLocation W12451799761 @default.
- W1245179976 hasConcept C104317684 @default.
- W1245179976 hasConcept C121608353 @default.
- W1245179976 hasConcept C126322002 @default.
- W1245179976 hasConcept C137738243 @default.
- W1245179976 hasConcept C142724271 @default.
- W1245179976 hasConcept C143998085 @default.
- W1245179976 hasConcept C1491633281 @default.
- W1245179976 hasConcept C173396325 @default.
- W1245179976 hasConcept C2778220009 @default.
- W1245179976 hasConcept C2779013556 @default.
- W1245179976 hasConcept C2780394083 @default.
- W1245179976 hasConcept C502942594 @default.
- W1245179976 hasConcept C526805850 @default.
- W1245179976 hasConcept C54355233 @default.