FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W124542690> ?p ?o ?g. }

• W124542690 endingPage "38" @default.
• W124542690 startingPage "27" @default.
• W124542690 abstract "Lysosomal enzymes are the products of 40-50 unlinked genes in the nucleus. Like membrane and secretory proteins, they are synthesized on membrane-bound ribosomes in the rough endoplasmic reticulum. They receive high-mannose oligosaccharide chains from lipid-linked intermediates on asparagine residues. They must be sorted from other proteins present in the lumen of the endoplasmic reticulum and delivered to the lysosomes. The best understood mechanism for this sorting and delivery involves the Man 6-P recognition system. The newly synthesized acid hydrolases acquire Man 6-P residues by a two-step reaction. First, GlcNAc 1-P is transferred to the C-6 position of the mannose residues which are present on the asparagine-linked high-mannose oligosaccharides. Then, N-acetylglucosamine residues are removed by the N-acetylglucosaminyl phosphoglycosidase to generate the Man 6-P monoester, which is capable of binding the Man 6-P receptor. Phosphorylated enzymes can then bind to Man 6-P receptors which collect into vesicles and bud off for delivery of enzymes to lysosomes. The region of the Golgi apparatus where the receptors containing newly synthesized enzymes bud off is not yet clear. Enzymes which fail to bind receptors are secreted. Some cell types express on their cell surfaces receptors which are capable of recapturing phosphorylated enzyme by receptor-mediated endocytosis. This secretion - recapture pathway provides an alternate route to lysosomes. Following delivery of enzyme to lysosomes, the enzymes undergo post-lysosomal processing by acid phosphotases, which remove the phosphomonoester groups, and acid proteases which reduce their size and trim off excess polypeptides. Although the evidence is very persuasive that enzymes can reach lysosomes by pathways that do not depend on the Man 6-P receptor, the mechanisms of Man 6-P receptor-independent segregation of acid hydrolases to lysosomes are totally unclear. In addition to this question, there are two other significant questions that remain to be answered. One of these is the precise intracellular route of newly synthesized enzyme. Where does the enzyme first bind receptor, and where does receptor actually bud off the Golgi apparatus to effect sorting? The second major question is really the central question of the mechanism of sorting of acid hydrolases. Although we know now that the sorting is effected through an enzyme which phosphorylates acid hydrolases, the question remains: How does the processing phosphotransferase distinguish acid hydrolases from other glycoproteins in the endoplasmic reticulum?(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W124542690 created "2016-06-24" @default.
• W124542690 creator A5071547468 @default.
• W124542690 date "1985-01-01" @default.
• W124542690 modified "2023-10-13" @default.
• W124542690 title "Receptor-Mediated Transport of Acid Hydrolases to Lysosomes" @default.
• W124542690 cites W1485846840 @default.
• W124542690 cites W1491202632 @default.
• W124542690 cites W1501325364 @default.
• W124542690 cites W1521136509 @default.
• W124542690 cites W1524337692 @default.
• W124542690 cites W1528373510 @default.
• W124542690 cites W1552593866 @default.
• W124542690 cites W1566105461 @default.
• W124542690 cites W1572734449 @default.
• W124542690 cites W1577635912 @default.
• W124542690 cites W158852521 @default.
• W124542690 cites W1606296697 @default.
• W124542690 cites W1731705023 @default.
• W124542690 cites W1871402408 @default.
• W124542690 cites W1965307985 @default.
• W124542690 cites W1967669651 @default.
• W124542690 cites W1973996457 @default.
• W124542690 cites W1981504260 @default.
• W124542690 cites W1985851452 @default.
• W124542690 cites W1990489268 @default.
• W124542690 cites W1998915477 @default.
• W124542690 cites W2001192613 @default.
• W124542690 cites W2001197606 @default.
• W124542690 cites W2008014078 @default.
• W124542690 cites W2008101816 @default.
• W124542690 cites W2011985054 @default.
• W124542690 cites W2020308706 @default.
• W124542690 cites W2023271648 @default.
• W124542690 cites W2031541160 @default.
• W124542690 cites W2031545291 @default.
• W124542690 cites W2034976029 @default.
• W124542690 cites W2036896268 @default.
• W124542690 cites W2039550296 @default.
• W124542690 cites W2041100747 @default.
• W124542690 cites W2049706113 @default.
• W124542690 cites W2062913738 @default.
• W124542690 cites W2067646403 @default.
• W124542690 cites W2070441244 @default.
• W124542690 cites W2077880358 @default.
• W124542690 cites W2080210883 @default.
• W124542690 cites W2085931205 @default.
• W124542690 cites W2086271423 @default.
• W124542690 cites W2091380888 @default.
• W124542690 cites W2095234199 @default.
• W124542690 cites W2097385470 @default.
• W124542690 cites W2120260066 @default.
• W124542690 cites W2122755820 @default.
• W124542690 cites W2125059835 @default.
• W124542690 cites W2130466615 @default.
• W124542690 cites W2133591889 @default.
• W124542690 cites W2143088883 @default.
• W124542690 cites W2167948410 @default.
• W124542690 cites W2173078011 @default.
• W124542690 cites W2257258720 @default.
• W124542690 cites W2344169908 @default.
• W124542690 cites W294303609 @default.
• W124542690 doi "https://doi.org/10.1016/b978-0-12-152826-3.50010-3" @default.
• W124542690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3000696" @default.
• W124542690 hasPublicationYear "1985" @default.
• W124542690 type Work @default.
• W124542690 sameAs 124542690 @default.
• W124542690 citedByCount "13" @default.
• W124542690 countsByYear W1245426902012 @default.
• W124542690 countsByYear W1245426902013 @default.
• W124542690 countsByYear W1245426902018 @default.
• W124542690 countsByYear W1245426902020 @default.
• W124542690 countsByYear W1245426902022 @default.
• W124542690 countsByYear W1245426902023 @default.
• W124542690 crossrefType "book-chapter" @default.
• W124542690 hasAuthorship W124542690A5071547468 @default.
• W124542690 hasConcept C119062480 @default.
• W124542690 hasConcept C120694314 @default.
• W124542690 hasConcept C158617107 @default.
• W124542690 hasConcept C170493617 @default.
• W124542690 hasConcept C181199279 @default.
• W124542690 hasConcept C202751555 @default.
• W124542690 hasConcept C2775887612 @default.
• W124542690 hasConcept C2775960820 @default.
• W124542690 hasConcept C2776205754 @default.
• W124542690 hasConcept C2778822930 @default.
• W124542690 hasConcept C2779244956 @default.
• W124542690 hasConcept C2780216420 @default.
• W124542690 hasConcept C28005876 @default.
• W124542690 hasConcept C49039625 @default.
• W124542690 hasConcept C55493867 @default.
• W124542690 hasConcept C6492254 @default.
• W124542690 hasConcept C86803240 @default.
• W124542690 hasConcept C95444343 @default.
• W124542690 hasConceptScore W124542690C119062480 @default.
• W124542690 hasConceptScore W124542690C120694314 @default.
• W124542690 hasConceptScore W124542690C158617107 @default.
• W124542690 hasConceptScore W124542690C170493617 @default.

• next