FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1245432933> ?p ?o ?g. }

• W1245432933 endingPage "284" @default.
• W1245432933 startingPage "281" @default.
• W1245432933 abstract "Type 2 diabetes mellitus (T2D) constitutes a growing global public health problem and its prevalence is estimated to increase during the next decades, especially in the developing countries. To date, 15 % of the whole population is considered at high risk to develop T2D [1]. T2D is associated with a decrease of health-related quality of life and overall life expectancy, mainly due to an increased risk for cardiovascular disorders. Indeed, T2D is commonly associated with both microvascular and macrovascular complications [2]. Macrovascular complications manifest themselves as accelerated atherosclerosis, clinically resulting in premature coronary artery disease, increased risk of cerebrovascular disease, and severe peripheral vascular disease [2]. Patients with T2D have a a twoto four-fold increase in the risk of coronary artery disease (CAD) and patients with DM but without previous myocardial infarction (MI) carry the same level of risk for subsequent acute coronary events as non-diabetic patients with previous MI [3, 4] so that T2D has been defined a CAD equivalent. T2D is associated with a prothrombotic state characterized by a number of changes in thrombotic and fibrinolytic coagulation factor level/activity, which together increase the risk of thrombus formation. Both glucose and insulin seem to play a role in the pathogenesis of this prothrombotic state [5]. In vitro induced thrombin generation is increased in platelet-rich plasma from diabetics compared with that from healthy subjects and a significant elevation of thrombin levels can be demonstrated in T2D patients in poor metabolic control when compared with well controlled patients [6].Moreover, a significant correlation can be observed between improved glycemic control and blood thrombogenicity, as reflected by a reduction in ex-vivo thrombus formation in a Badimon perfusion chamber [7]. Improved glycemic control is the only significant predictor of a decrease in blood thrombogenicity, irrespective of treatment allocation [7]. Enhanced levels of prothrombin fragment 1+2 (F1+2) and thrombin-antithrombin complexes (TAT) have been shown in T2D patients in comparison with healthy subjects [8]. A hypercoagulable state, detected by thrombin generation tests, was reported in patients with T2D, explaining, at least partially, the high incidence of vascular events in these patients [9]. Platelets of patients with DM are characterized by dysregulation of several signaling pathways, leading to an hyperreactive phenotype with enhanced adhesion, aggregation, and activation [10]. Chronic hyperglycemia has been clearly identified as a causal factor for in vivo platelet activation [11]. Our group firstly demonstrated enhanced thromboxane (TX) biosynthesis in T2D, providing evidence for its platelet origin. Moreover, tight metabolic control led to reduction of TX metabolite urinary levels [11]. Interestingly, inflammatory mediators (such as CD40L) derived from platelets expand the functional repertoire of platelets from players of hemostasis and thrombosis to powerful amplifiers of inflammation by promoting the release of cytokines and chemokines, cell activation and cell–cell interactions [12]. T2D is frequently associated with a dyslipidemic state that may accelerate the progression of atherosclerotic F. Perego Internal Medicine III, Luigi Sacco Hospital, University of Milan, Milan, Italy" @default.
• W1245432933 created "2016-06-24" @default.
• W1245432933 creator A5010013725 @default.
• W1245432933 creator A5068277085 @default.
• W1245432933 date "2012-05-15" @default.
• W1245432933 modified "2023-09-27" @default.
• W1245432933 title "Beyond Hyperglycemia in Diabetes: Role of Statin Treatment on Thrombogenesis Triggered by Inflammation" @default.
• W1245432933 cites W1903216452 @default.
• W1245432933 cites W1966562996 @default.
• W1245432933 cites W1969956137 @default.
• W1245432933 cites W1976369579 @default.
• W1245432933 cites W1986076893 @default.
• W1245432933 cites W1990799442 @default.
• W1245432933 cites W1992906399 @default.
• W1245432933 cites W2005998137 @default.
• W1245432933 cites W2034485512 @default.
• W1245432933 cites W2057651652 @default.
• W1245432933 cites W2058217708 @default.
• W1245432933 cites W2058463415 @default.
• W1245432933 cites W2068898353 @default.
• W1245432933 cites W2074410191 @default.
• W1245432933 cites W2077210107 @default.
• W1245432933 cites W2079115892 @default.
• W1245432933 cites W2097870088 @default.
• W1245432933 cites W2116096080 @default.
• W1245432933 cites W2124341770 @default.
• W1245432933 cites W2130549133 @default.
• W1245432933 cites W2140396611 @default.
• W1245432933 cites W2331274940 @default.
• W1245432933 cites W4254903588 @default.
• W1245432933 doi "https://doi.org/10.1007/s10557-012-6398-9" @default.
• W1245432933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22585309" @default.
• W1245432933 hasPublicationYear "2012" @default.
• W1245432933 type Work @default.
• W1245432933 sameAs 1245432933 @default.
• W1245432933 citedByCount "3" @default.
• W1245432933 countsByYear W12454329332018 @default.
• W1245432933 countsByYear W12454329332021 @default.
• W1245432933 crossrefType "journal-article" @default.
• W1245432933 hasAuthorship W1245432933A5010013725 @default.
• W1245432933 hasAuthorship W1245432933A5068277085 @default.
• W1245432933 hasBestOaLocation W12454329331 @default.
• W1245432933 hasConcept C126322002 @default.
• W1245432933 hasConcept C134018914 @default.
• W1245432933 hasConcept C177713679 @default.
• W1245432933 hasConcept C2776839432 @default.
• W1245432933 hasConcept C2776914184 @default.
• W1245432933 hasConcept C2910980524 @default.
• W1245432933 hasConcept C555293320 @default.
• W1245432933 hasConcept C60644358 @default.
• W1245432933 hasConcept C71924100 @default.
• W1245432933 hasConcept C86803240 @default.
• W1245432933 hasConceptScore W1245432933C126322002 @default.
• W1245432933 hasConceptScore W1245432933C134018914 @default.
• W1245432933 hasConceptScore W1245432933C177713679 @default.
• W1245432933 hasConceptScore W1245432933C2776839432 @default.
• W1245432933 hasConceptScore W1245432933C2776914184 @default.
• W1245432933 hasConceptScore W1245432933C2910980524 @default.
• W1245432933 hasConceptScore W1245432933C555293320 @default.
• W1245432933 hasConceptScore W1245432933C60644358 @default.
• W1245432933 hasConceptScore W1245432933C71924100 @default.
• W1245432933 hasConceptScore W1245432933C86803240 @default.
• W1245432933 hasIssue "4" @default.
• W1245432933 hasLocation W12454329331 @default.
• W1245432933 hasLocation W12454329332 @default.
• W1245432933 hasOpenAccess W1245432933 @default.
• W1245432933 hasPrimaryLocation W12454329331 @default.
• W1245432933 hasRelatedWork W2082804793 @default.
• W1245432933 hasRelatedWork W2109417731 @default.
• W1245432933 hasRelatedWork W2127396703 @default.
• W1245432933 hasRelatedWork W2472770293 @default.
• W1245432933 hasRelatedWork W2511670019 @default.
• W1245432933 hasRelatedWork W2748952813 @default.
• W1245432933 hasRelatedWork W3000658577 @default.
• W1245432933 hasRelatedWork W4226226762 @default.
• W1245432933 hasRelatedWork W4255671940 @default.
• W1245432933 hasRelatedWork W4378072516 @default.
• W1245432933 hasVolume "26" @default.
• W1245432933 isParatext "false" @default.
• W1245432933 isRetracted "false" @default.
• W1245432933 magId "1245432933" @default.
• W1245432933 workType "article" @default.