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- W1245494941 endingPage "510" @default.
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- W1245494941 abstract "Multiple neurotransmitter systems are affected in senile dementia of the Alzheimer's type (SDAT). Among them, acetylcholine has been most studied. It is now well accepted that the activity of the enzyme, choline acetyltransferase (ChAT) is much decreased in various brain regions including the frontal and temporal cortices, hippocampus and nucleus basalis of Meynert (nbm) in SDAT. Cortical M2-muscarinic and nicotinic cholinergic receptors are also decreased but only in a certain proportion (30-40%) of SDAT patients. For other systems, it appears that cortical serotonin (5-HT)-type 2 receptor binding sites are decreased in SDAT. This diminution in 5-HT2 receptors correlates well with the decreased levels of somatostatin-like immunoreactive materials found in the cortex of SDAT patients. Cortical somatostatin receptor binding sites are decreased in about one third of SDAT patients. Finally, neuropeptide Y and neuropeptide Y receptor binding sites are distributed in areas enriched in cholinergic cell bodies and nerve fiber terminals and it would be of interest to determine possible involvement of this peptide in SDAT. Thus, it appears that multi-drug clinical trials should be considered for the treatment of SDAT." @default.
- W1245494941 created "2016-06-24" @default.
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- W1245494941 date "1986-11-01" @default.
- W1245494941 modified "2023-09-28" @default.
- W1245494941 title "Neurotransmitter and Receptor Deficits in Senile Dementia of the Alzheimer Type" @default.
- W1245494941 cites W1965420525 @default.
- W1245494941 cites W1968053343 @default.
- W1245494941 cites W1968630050 @default.
- W1245494941 cites W1968634235 @default.
- W1245494941 cites W1970426318 @default.
- W1245494941 cites W1979228270 @default.
- W1245494941 cites W1982064952 @default.
- W1245494941 cites W1982719361 @default.
- W1245494941 cites W1985429753 @default.
- W1245494941 cites W1991185591 @default.
- W1245494941 cites W1994067502 @default.
- W1245494941 cites W1995673609 @default.
- W1245494941 cites W1996649288 @default.
- W1245494941 cites W1996937956 @default.
- W1245494941 cites W1997498976 @default.
- W1245494941 cites W2000196736 @default.
- W1245494941 cites W2001664582 @default.
- W1245494941 cites W2002182550 @default.
- W1245494941 cites W2004713321 @default.
- W1245494941 cites W2005453961 @default.
- W1245494941 cites W2008390348 @default.
- W1245494941 cites W2009459237 @default.
- W1245494941 cites W2011279980 @default.
- W1245494941 cites W2012432946 @default.
- W1245494941 cites W2016254753 @default.
- W1245494941 cites W2016385519 @default.
- W1245494941 cites W2017743538 @default.
- W1245494941 cites W2021280501 @default.
- W1245494941 cites W2026136209 @default.
- W1245494941 cites W2026545343 @default.
- W1245494941 cites W2027795892 @default.
- W1245494941 cites W2028394019 @default.
- W1245494941 cites W2030955576 @default.
- W1245494941 cites W2032046308 @default.
- W1245494941 cites W2032768837 @default.
- W1245494941 cites W2033041856 @default.
- W1245494941 cites W2034046047 @default.
- W1245494941 cites W2034969383 @default.
- W1245494941 cites W2036923270 @default.
- W1245494941 cites W2037047980 @default.
- W1245494941 cites W2037512229 @default.
- W1245494941 cites W2039020023 @default.
- W1245494941 cites W2042234850 @default.
- W1245494941 cites W2043991242 @default.
- W1245494941 cites W2044051265 @default.
- W1245494941 cites W2044862890 @default.
- W1245494941 cites W2044899556 @default.
- W1245494941 cites W2047397000 @default.
- W1245494941 cites W2048365745 @default.
- W1245494941 cites W2049090946 @default.
- W1245494941 cites W2054380826 @default.
- W1245494941 cites W2054579183 @default.
- W1245494941 cites W2059771394 @default.
- W1245494941 cites W2061156895 @default.
- W1245494941 cites W2065347688 @default.
- W1245494941 cites W2066331032 @default.
- W1245494941 cites W2067624003 @default.
- W1245494941 cites W2068118637 @default.
- W1245494941 cites W2068425062 @default.
- W1245494941 cites W2071246615 @default.
- W1245494941 cites W2071569187 @default.
- W1245494941 cites W2072798024 @default.
- W1245494941 cites W2076433885 @default.
- W1245494941 cites W2077859295 @default.
- W1245494941 cites W2078294321 @default.
- W1245494941 cites W2078328195 @default.
- W1245494941 cites W2080275842 @default.
- W1245494941 cites W2080781505 @default.
- W1245494941 cites W2081149280 @default.
- W1245494941 cites W2081880500 @default.
- W1245494941 cites W2087310502 @default.
- W1245494941 cites W2088295947 @default.
- W1245494941 cites W2090814796 @default.
- W1245494941 cites W2091492013 @default.
- W1245494941 cites W2093123126 @default.
- W1245494941 cites W2093374391 @default.
- W1245494941 cites W2093460641 @default.
- W1245494941 cites W2094831046 @default.
- W1245494941 cites W2095477109 @default.
- W1245494941 cites W2097230605 @default.
- W1245494941 cites W2104227586 @default.
- W1245494941 cites W2107061279 @default.
- W1245494941 cites W2111493525 @default.
- W1245494941 cites W2111581233 @default.
- W1245494941 cites W2163254941 @default.
- W1245494941 cites W2411008291 @default.