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- W1245783 abstract "Most of the isoprenoids have been isolated from eukaryotes such as plants and fungi. However, actinomycete strains, which are known to produce many kinds of nonribosomal peptides and polyketides, have recently been reported to produce many types of isoprenoids. In many cases, isoprenoid moieties of compounds produced by actinomycetes are attached to other moieties, such as a polyketide, an aromatic ring, and an amino acid, that are synthesized via pathways independent of isoprenoid synthesis, to give the so-called isoprenoid hybrid compounds, in contrast to eukaryotic isoprenoids, which usually have cyclic structures that are formed by cyclization of geranyl diphosphate (GDP), farnesyl diphosphate (FDP), and geranylgeranyl diphosphate (GGDP). The structures of prokaryotic isoprenoids, therefore, are unique and different from those of eukaryotic origin. In this article, the structural diversity of isoprenoids produced by actinomycetes is summarized. Besides the structural diversity, biosynthetic studies on genes and enzymes responsible for biosynthesis of these isoprenoids are also described since many studies in this line have been reported after ‘Comprehensive Natural Product Chemistry’ published in 1999." @default.
- W1245783 created "2016-06-24" @default.
- W1245783 creator A5063530297 @default.
- W1245783 date "2013-01-01" @default.
- W1245783 modified "2023-09-23" @default.
- W1245783 title "Isoprenoid in Actinomycetes" @default.
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