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- W12465440 abstract "To determine the potential roles of retinoids in the growth and differentiation of the reproductive tract epithelium, we have studied the expression of the cellular retinol- and retinoic acid-binding proteins, CRBP I and CRABP I, in the reproductive tract of female rats. CRBP I and CRABP I gene expression have been examined in the oviduct, ovary, uterus, and particularly in the cervix, which normally undergoes a cyclical squamous metaplasia during the estrus cycle. CRBP I was expressed in all four tissues examined, whereas CRABP I was expressed predominantly in cervix and uterus. In the cervix, CRBP I was detected in all epithelial layers including the columnar epithelium but was greatly reduced in the superficial, cornified layers of the stratified squamous epithelium. CRABP I was localized to the basement membrane region of the epithelium with the strongest expression in the basal layer of epithelial cells. While the expression of CRBP I and CRABP I in the keratinizing exocervix changed during the estrus cycle, it remained constant in the incompletely keratinized endocervix. The highest levels of CRBP I were seen during anestrus and proestrus, and for CRABP I during proestrus. Both CRBP I and CRABP I levels fell to barely detectable levels during estrus and metestrus. Using estrogen repletion of ovariectomized rats, we found that CRABP I levels transiently increased during the early proliferative response to estrogen, whereas CRBP I levels gradually declined, becoming barely detectable by 24 to 48 hours. These results suggest that CRBP I and CRABP I play different roles in the cyclical squamous metaplasia normally occurring in this tissue and that hormonal control of CRBP I and CRABP I expression might modulate the retinoid responsiveness of the epithelium during this process." @default.
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- W12465440 date "1994-01-01" @default.
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- W12465440 title "Expression of cellular retinol- and cellular retinoic acid-binding proteins in the rat cervical epithelium is regulated by endocrine stimuli during normal squamous metaplasia." @default.
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