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- W124664279 abstract "The introduction of monoclonal antibodies against checkpoint inhibitors on T cells such as Ipilimumab and anti PD1 has been a major advance in the treatment of metastatic melanoma. Nevertheless, the majority of patients does not receive benefit from this treatment approach. The reasons for this are likely to reflect conditioning of the microenvironment of the tumour by properties of the tumour cells that either prevent infiltration by T cells or which modulate their function. Treatments that combine monoclonal antibodies with agents that inhibit melanoma cell production of suppressive cytokines and which favor infiltration of T cells into the tumour are the focus of ongoing studies." @default.
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- W124664279 date "2013-01-01" @default.
- W124664279 modified "2023-09-23" @default.
- W124664279 title "Overcoming Resistance of Melanoma to Immunotherapy with Monoclonal Antibodies Against Checkpoints Inhibitors" @default.
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- W124664279 doi "https://doi.org/10.1007/978-1-4614-7654-2_7" @default.
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