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- W1247180103 abstract "A high-performance liquid chromatographic method for the simultaneousdetermination of KR-008 and its metabolite in biological fluids was developed The samples wereinjected directly without further treatment,the compounds were separated and analysed on a reversed-phase column under isocratic conditions,including ion pairing.Concentrations in urine and bile weredetermined by an external standard method.The detection limit was 0.8μg/ml in urine.Preliminarydata showed that,following i.p.administration(120mg/kg)of KR-008 to rats,approximately 2.8% ofthe dose was excreted in urine as unchanged compound and more than 8.9% was as a metabolite;inbile it was 0.73% excreted as unchanged form and above 0.29% as the metabolite.The peak biliaryconcentration of KR-008 was 0.39mg/ml at 20min after dosing." @default.
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- W1247180103 date "1993-01-01" @default.
- W1247180103 modified "2023-09-24" @default.
- W1247180103 title "HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF KR-008 IN BIOLOGICAL FLUIDS" @default.
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