Matches in SemOpenAlex for { <https://semopenalex.org/work/W124802934> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W124802934 abstract "Introduction: Accumulation of ubiquitinated proteins and aggregates are increasingly being recognized as playing major roles in cardiac disease and heart failure. Recent work suggests that a protein named p62 plays a regulatory role in the accumulation of ubiquitinated proteins and protein aggregates. Chronic hemodynamic stress causes cardiac hypertrophy and triggers a concomitant increase in p62 and ubiquitinated protein levels. Hypothesis: p62 expression contributes to proteotoxic accumulation and cardiac hypertrophy. Methods: An adenovirus was created to drive p62 expression in neonatal cardiomyocytes to study role of p62 in cardiac cell growth and proteotoxic accumulation. Trans-aortic constriction or sham surgeries were performed on wild-type and p62-deficient mice to test if p62 was necessary for pressure-overload induced hypertrophy and pathology. Results: Overexpression of p62 in cardiomyocytes significantly increased cardiomyocyte size and caused a corresponding increase in aggregate accumulation..." @default.
- W124802934 created "2016-06-24" @default.
- W124802934 creator A5005272366 @default.
- W124802934 creator A5024726678 @default.
- W124802934 creator A5025122140 @default.
- W124802934 creator A5057815689 @default.
- W124802934 date "2012-11-20" @default.
- W124802934 modified "2023-09-24" @default.
- W124802934 title "Abstract 11890: Defining the Role of p62 in Cardiac Hypertrophy and Pathology" @default.
- W124802934 hasPublicationYear "2012" @default.
- W124802934 type Work @default.
- W124802934 sameAs 124802934 @default.
- W124802934 citedByCount "0" @default.
- W124802934 crossrefType "journal-article" @default.
- W124802934 hasAuthorship W124802934A5005272366 @default.
- W124802934 hasAuthorship W124802934A5024726678 @default.
- W124802934 hasAuthorship W124802934A5025122140 @default.
- W124802934 hasAuthorship W124802934A5057815689 @default.
- W124802934 hasConcept C104317684 @default.
- W124802934 hasConcept C126322002 @default.
- W124802934 hasConcept C134018914 @default.
- W124802934 hasConcept C167414201 @default.
- W124802934 hasConcept C190283241 @default.
- W124802934 hasConcept C203522944 @default.
- W124802934 hasConcept C25602115 @default.
- W124802934 hasConcept C2778198053 @default.
- W124802934 hasConcept C2778271984 @default.
- W124802934 hasConcept C2781452922 @default.
- W124802934 hasConcept C3018791406 @default.
- W124802934 hasConcept C55493867 @default.
- W124802934 hasConcept C71924100 @default.
- W124802934 hasConcept C86803240 @default.
- W124802934 hasConcept C95444343 @default.
- W124802934 hasConceptScore W124802934C104317684 @default.
- W124802934 hasConceptScore W124802934C126322002 @default.
- W124802934 hasConceptScore W124802934C134018914 @default.
- W124802934 hasConceptScore W124802934C167414201 @default.
- W124802934 hasConceptScore W124802934C190283241 @default.
- W124802934 hasConceptScore W124802934C203522944 @default.
- W124802934 hasConceptScore W124802934C25602115 @default.
- W124802934 hasConceptScore W124802934C2778198053 @default.
- W124802934 hasConceptScore W124802934C2778271984 @default.
- W124802934 hasConceptScore W124802934C2781452922 @default.
- W124802934 hasConceptScore W124802934C3018791406 @default.
- W124802934 hasConceptScore W124802934C55493867 @default.
- W124802934 hasConceptScore W124802934C71924100 @default.
- W124802934 hasConceptScore W124802934C86803240 @default.
- W124802934 hasConceptScore W124802934C95444343 @default.
- W124802934 hasLocation W1248029341 @default.
- W124802934 hasOpenAccess W124802934 @default.
- W124802934 hasPrimaryLocation W1248029341 @default.
- W124802934 hasRelatedWork W147478340 @default.
- W124802934 hasRelatedWork W2050943857 @default.
- W124802934 hasRelatedWork W2071710704 @default.
- W124802934 hasRelatedWork W2101080348 @default.
- W124802934 hasRelatedWork W2105199639 @default.
- W124802934 hasRelatedWork W2109099780 @default.
- W124802934 hasRelatedWork W2115013104 @default.
- W124802934 hasRelatedWork W2150278759 @default.
- W124802934 hasRelatedWork W2259938465 @default.
- W124802934 hasRelatedWork W2274090752 @default.
- W124802934 hasRelatedWork W2744938773 @default.
- W124802934 hasRelatedWork W2757365300 @default.
- W124802934 hasRelatedWork W2770493378 @default.
- W124802934 hasRelatedWork W2804725503 @default.
- W124802934 hasRelatedWork W2898677682 @default.
- W124802934 hasRelatedWork W2970718403 @default.
- W124802934 hasRelatedWork W3113911427 @default.
- W124802934 hasRelatedWork W3159364440 @default.
- W124802934 hasRelatedWork W3175233343 @default.
- W124802934 hasRelatedWork W2262110752 @default.
- W124802934 hasVolume "126" @default.
- W124802934 isParatext "false" @default.
- W124802934 isRetracted "false" @default.
- W124802934 magId "124802934" @default.
- W124802934 workType "article" @default.