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• W125012758 abstract "This method describes a microarray-based platform to perform nucleic acid selections. Chemical ligands to which a nucleic acid binder is desired are immobilized onto an agarose microarray surface; the array is then incubated with an RNA library. Bound RNA library members are harvested directly from the array surface via gel excision at the position on the array where a ligand was immobilized. The RNA is then amplified via RT-PCR, cloned, and sequenced. This method has the following advantages over traditional resin-based Systematic Evolution of Ligands by Exponential Enrichment (SELEX): (1) multiple selections can be completed in parallel on a single microarray surface; (2) kinetic biases in the selections are mitigated since all RNA binders are harvested from an array via gel excision; (3) the amount of chemical ligand needed to perform a selection is minimized; (4) selections do not require expensive resins or equipment; and (5) the matrix used for selections is inexpensive and easy to prepare. Although this protocol was demonstrated for RNA selections, it should be applicable for any nucleic acid selection." @default.
• W125012758 created "2016-06-24" @default.
• W125012758 creator A5017275370 @default.
• W125012758 creator A5050625441 @default.
• W125012758 date "2010-01-01" @default.
• W125012758 modified "2023-09-26" @default.
• W125012758 title "A Microarray-Based Method to Perform Nucleic Acid Selections" @default.
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• W125012758 doi "https://doi.org/10.1007/978-1-60761-845-4_17" @default.
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