Matches in SemOpenAlex for { <https://semopenalex.org/work/W1250328549> ?p ?o ?g. }
- W1250328549 abstract "Lectinas sao proteinas e/ou glicoproteinas de origem nao imune que possuem, no minimo, um sitio nao-catalitico que se liga de forma reversivel a carboidratos e glicoconjugados, o que as tornam modelos ideais de estudos de interacoes celula-celula, celula-virus, sendo bons modelos para o desenho de novos farmacos. Algumas proteinas possuem capacidade de se ligar a carboidratos, assemelhando-se as lectinas, porem com algumas diferencas estruturais e funcionais, que as excluem desse grupo. A Fabaceae Acacia farnesiana possui em suas sementes uma aglutinina ligante de quitina (AFAL), classificada como PHA-like1. Seu padrao cromatografico revelou oligomerizacao tempo-dependente. Esse comportamento dinâmico dificulta a cristalizacao dessa proteina, bem como determinacao da estrutura tridimensional. Visando compreender melhor a relacao estrutura-funcao, este trabalho teve por objetivo analisar a atividade anti-inflamatoria de AFAL atraves de comparacao estrutural com lectinas de leguminosas. Para tanto, fez-se a modelagem e docking molecular com um glicano e a carragenina. A AFAL apresentou um modelo dobrado como um sanduiche de folhas β, que difere do molde utilizado (lectina de Pisum sativum) em regioes de loops, no numero de folhas β e no sitio de ligacao a carboidratos. O docking revelou que a proteina se liga a carragenina e ao glicano em sitios diferentes, o que pode ser explicado pela ausencia de uma sexta folha β frontal e de duas folhas β na regiao posterior. A aglutinina de A. farnesiana pode inibir a inflamacao causada por carragenina, por se ligar a ela, impedindo sua entrada na celula e o desencadeamento de reacoes tipicas do processo inflamatorio." @default.
- W1250328549 created "2016-06-24" @default.
- W1250328549 creator A5060212781 @default.
- W1250328549 date "2013-02-21" @default.
- W1250328549 modified "2023-09-25" @default.
- W1250328549 title "A modelagem molecular da proteína pha-like de Acacia Farnesiana revela mecanismo anti-inflamatório" @default.
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