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- W1250804522 abstract "Pyroglutamate-3 amyloid-beta (pGlu-3 Aβ) is an N-terminally truncated Aβ isoform likely playing a decisive role in Alzheimer's disease pathogenesis. Here, we describe a prophylactic passive immunization study in APPswe/PS1ΔE9 mice using a novel pGlu-3 Aβ immunoglobulin G1 (IgG1) monoclonal antibody, 07/1 (150 and 500 μg, intraperitoneal, weekly) and compare its efficacy with a general Aβ IgG1 monoclonal antibody, 3A1 (200 μg, intraperitoneal, weekly) as a positive control. After 28 weeks of treatment, plaque burden was reduced and cognitive performance of 07/1-immunized Tg mice, especially at the higher dose, was normalized to wild-type levels in 2 hippocampal-dependent tests and partially spared compared with phosphate-buffered saline-treated Tg mice. Mice that received 3A1 had reduced plaque burden but showed no cognitive benefit. In contrast with 3A1, treatment with 07/1 did not increase the concentration of Aβ in plasma, suggesting different modes of Aβ plaque clearance. In conclusion, early selective targeting of pGlu-3 Aβ by immunotherapy may be effective in lowering cerebral Aβ plaque burden and preventing cognitive decline in the clinical setting. Targeting this pathologically modified form of Aβ thereby is unlikely to interfere with potential physiologic function(s) of Aβ that have been proposed." @default.
- W1250804522 created "2016-06-24" @default.
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- W1250804522 date "2015-12-01" @default.
- W1250804522 modified "2023-10-12" @default.
- W1250804522 title "An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice" @default.
- W1250804522 cites W1494074009 @default.
- W1250804522 cites W1517477926 @default.
- W1250804522 cites W1528113046 @default.
- W1250804522 cites W1552912270 @default.
- W1250804522 cites W1564371178 @default.
- W1250804522 cites W1567490604 @default.
- W1250804522 cites W1587774683 @default.
- W1250804522 cites W1597819025 @default.
- W1250804522 cites W1607136952 @default.
- W1250804522 cites W1927066019 @default.
- W1250804522 cites W1967549235 @default.
- W1250804522 cites W1974145718 @default.
- W1250804522 cites W1975578749 @default.
- W1250804522 cites W1979415323 @default.
- W1250804522 cites W1979818695 @default.
- W1250804522 cites W1980206150 @default.
- W1250804522 cites W1982707819 @default.
- W1250804522 cites W1985323612 @default.
- W1250804522 cites W1986711108 @default.
- W1250804522 cites W1990632702 @default.
- W1250804522 cites W1995974605 @default.
- W1250804522 cites W2000917982 @default.
- W1250804522 cites W2001082811 @default.
- W1250804522 cites W2002520289 @default.
- W1250804522 cites W2005719973 @default.
- W1250804522 cites W2006761942 @default.
- W1250804522 cites W2010357514 @default.
- W1250804522 cites W2015349765 @default.
- W1250804522 cites W2016920663 @default.
- W1250804522 cites W2020824841 @default.
- W1250804522 cites W2024656644 @default.
- W1250804522 cites W2024866120 @default.
- W1250804522 cites W2024917017 @default.
- W1250804522 cites W2026156322 @default.
- W1250804522 cites W2026326610 @default.
- W1250804522 cites W2028379029 @default.
- W1250804522 cites W2028757687 @default.
- W1250804522 cites W2028938218 @default.
- W1250804522 cites W2032958786 @default.
- W1250804522 cites W2033385065 @default.
- W1250804522 cites W2035564116 @default.
- W1250804522 cites W2039716280 @default.
- W1250804522 cites W2046077888 @default.
- W1250804522 cites W2059050392 @default.
- W1250804522 cites W2059212904 @default.
- W1250804522 cites W2060851420 @default.
- W1250804522 cites W2070887142 @default.
- W1250804522 cites W2071310220 @default.
- W1250804522 cites W2076742349 @default.
- W1250804522 cites W2078917784 @default.
- W1250804522 cites W2080705044 @default.
- W1250804522 cites W2081388499 @default.
- W1250804522 cites W2082044837 @default.
- W1250804522 cites W2082429191 @default.
- W1250804522 cites W2088282114 @default.
- W1250804522 cites W2090586279 @default.
- W1250804522 cites W2095253097 @default.
- W1250804522 cites W2096410114 @default.
- W1250804522 cites W2097338951 @default.
- W1250804522 cites W2102347098 @default.
- W1250804522 cites W2108629610 @default.
- W1250804522 cites W2112488212 @default.
- W1250804522 cites W2113759533 @default.
- W1250804522 cites W2121948289 @default.
- W1250804522 cites W2122843800 @default.
- W1250804522 cites W2127458156 @default.
- W1250804522 cites W2130270031 @default.
- W1250804522 cites W2133595485 @default.
- W1250804522 cites W2142943752 @default.
- W1250804522 cites W2152286012 @default.
- W1250804522 cites W2154735761 @default.
- W1250804522 cites W2160676126 @default.
- W1250804522 cites W2162124438 @default.
- W1250804522 cites W2163202463 @default.
- W1250804522 cites W2164535032 @default.
- W1250804522 cites W2166142595 @default.
- W1250804522 cites W2170241219 @default.
- W1250804522 cites W4313105713 @default.
- W1250804522 doi "https://doi.org/10.1016/j.neurobiolaging.2015.08.021" @default.
- W1250804522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4641825" @default.
- W1250804522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26453001" @default.
- W1250804522 hasPublicationYear "2015" @default.