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- W125177492 abstract "The promise of radiolabeled monoclonal antibodies (MAb’s) as site-specific radiopharmaceuticals in medical diagnosis and therapy (1) has increased the need for bifunctional chelators which couple MAb’s with diagnostic and/or therapeutic radionuclides. A bifunctional chelator combines a metal-sequestering ligand with a functional group which can be covalently linked to a biologically active molecule. Because MAb’s generally do not bind metals, bifunctional chelators are needed to attach one or more metallic radionuclides to these important proteins. Metallothioneins (MT’s) bind as many as twenty atoms of a wide variety of metals and thus offer unique potential as bifunctional chelators." @default.
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- W125177492 date "1987-01-01" @default.
- W125177492 modified "2023-09-23" @default.
- W125177492 title "Metallothionein: A Bifunctional Chelator for the Radiolabeling of Biologically Active Molecules" @default.
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- W125177492 doi "https://doi.org/10.1007/978-3-0348-6784-9_19" @default.
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