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- W125180866 abstract "G-protein coupled receptors (GPCR) tend to desensitize/internalize when exposed to excess agonist.Previously, we have supported the argument that in the case of the oxytocin receptor (OTR), excess agonist (oxytocin, OT) at birth could be implicated with behavioural disorders of the autistic spectrum. In this review, more recent evidence for this hypothesis is summarized, and it is juxtaposed against reports where exogenous OT was found beneficial in alleviating certain undesired behaviours. Facing this dichotomy, we suggest possible in silico drug discovery approaches to mitigate undesired side effect of OT administration/OTR desensitization, especially in the light of potentially emerging agonist therapies. For this, the most important structural features of OTR are reviewed, and we highlight here the need for higher level of theory studies at the easier approachable extracellular receptor side, where loop 3(e3) and the N-terminated strain of OTR appear to offer targets of particular interest for the development of an agent that conditions the action of excess OT. Another approach, based on the development of new agonists with an improved receptor activation to receptor phosphorylation ratio, is also discussed. Finally, the issue of OTR desensitization is put into the broader context of GPCR desensitization and possible implications for behavioural disorders, and the case is made for the usefulness of computational studies in this area." @default.
- W125180866 created "2016-06-24" @default.
- W125180866 creator A5025501437 @default.
- W125180866 date "2007-07-01" @default.
- W125180866 modified "2023-09-23" @default.
- W125180866 title "G-protein coupled receptors & autism -- reflections on a double-edged sword at the example of the oxytocin receptor system." @default.
- W125180866 cites W132590214 @default.
- W125180866 cites W1485849821 @default.
- W125180866 cites W1523866988 @default.
- W125180866 cites W1602757251 @default.
- W125180866 cites W1635412086 @default.
- W125180866 cites W1846280845 @default.
- W125180866 cites W1968021269 @default.
- W125180866 cites W1970134980 @default.
- W125180866 cites W1972383590 @default.
- W125180866 cites W1975286549 @default.
- W125180866 cites W1978748770 @default.
- W125180866 cites W1980534989 @default.
- W125180866 cites W1980625058 @default.
- W125180866 cites W1981395216 @default.
- W125180866 cites W1987389454 @default.
- W125180866 cites W1990439063 @default.
- W125180866 cites W1990991790 @default.
- W125180866 cites W1991442209 @default.
- W125180866 cites W1991517520 @default.
- W125180866 cites W1996695876 @default.
- W125180866 cites W1997120050 @default.
- W125180866 cites W2000521278 @default.
- W125180866 cites W2001626986 @default.
- W125180866 cites W2003194288 @default.
- W125180866 cites W2011001109 @default.
- W125180866 cites W2011232072 @default.
- W125180866 cites W2011828358 @default.
- W125180866 cites W2013644351 @default.
- W125180866 cites W2014102714 @default.
- W125180866 cites W2016359852 @default.
- W125180866 cites W2016557481 @default.
- W125180866 cites W2017323063 @default.
- W125180866 cites W2020774161 @default.
- W125180866 cites W2025046733 @default.
- W125180866 cites W2026554384 @default.
- W125180866 cites W2027523671 @default.
- W125180866 cites W2033388874 @default.
- W125180866 cites W2033597006 @default.
- W125180866 cites W2036441276 @default.
- W125180866 cites W2037834475 @default.
- W125180866 cites W2040540346 @default.
- W125180866 cites W2042440594 @default.
- W125180866 cites W2042916273 @default.
- W125180866 cites W2047782979 @default.
- W125180866 cites W2050947021 @default.
- W125180866 cites W2053849177 @default.
- W125180866 cites W2054199028 @default.
- W125180866 cites W2057972330 @default.
- W125180866 cites W2060536455 @default.
- W125180866 cites W2064311417 @default.
- W125180866 cites W2068042896 @default.
- W125180866 cites W2068362148 @default.
- W125180866 cites W2071652062 @default.
- W125180866 cites W2072795452 @default.
- W125180866 cites W2076236871 @default.
- W125180866 cites W2082859469 @default.
- W125180866 cites W2082992054 @default.
- W125180866 cites W2083334427 @default.
- W125180866 cites W2084931825 @default.
- W125180866 cites W2086586090 @default.
- W125180866 cites W2087877032 @default.
- W125180866 cites W2090664128 @default.
- W125180866 cites W2094287722 @default.
- W125180866 cites W2094712734 @default.
- W125180866 cites W2095507812 @default.
- W125180866 cites W2095866179 @default.
- W125180866 cites W2096250412 @default.
- W125180866 cites W2097186487 @default.
- W125180866 cites W2097365951 @default.
- W125180866 cites W2097841147 @default.
- W125180866 cites W2101382188 @default.
- W125180866 cites W2105416365 @default.
- W125180866 cites W2106233797 @default.
- W125180866 cites W2114374730 @default.
- W125180866 cites W2115018134 @default.
- W125180866 cites W2121748618 @default.
- W125180866 cites W2122052848 @default.
- W125180866 cites W2130783152 @default.
- W125180866 cites W2132033525 @default.
- W125180866 cites W2135720675 @default.
- W125180866 cites W2138559331 @default.
- W125180866 cites W2146239303 @default.
- W125180866 cites W2147104519 @default.
- W125180866 cites W2149939379 @default.
- W125180866 cites W2149963584 @default.
- W125180866 cites W2152096508 @default.
- W125180866 cites W2160600642 @default.
- W125180866 cites W2160864268 @default.
- W125180866 cites W2162203550 @default.
- W125180866 cites W2163352150 @default.
- W125180866 cites W2164846680 @default.
- W125180866 cites W2165266294 @default.