Matches in SemOpenAlex for { <https://semopenalex.org/work/W125201431> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W125201431 endingPage "5" @default.
- W125201431 startingPage "261" @default.
- W125201431 abstract "Three human volunteers were successfully protected against sporozoite challenge by immunization with attenuated sporozoites of the Tamenie strain of Plasmodium falciparum from Ethiopia. The immunizing sporozoites were attenuated by exposing infected Anopheles stephensi mosquitos to X-rays at a dose of at least 120 Gy (12 000 rad). These irradiated, infected mosquitos were allowed to feed upon volunteers, thereby inoculating sporozoites into their blood stream. During the 10- to 38-week period of immunization, volunteers were exposed 6-8 times, at irregular intervals, to a total of 440-987 irradiated infected mosquitos. Protection against challenge by nonirradiated infected mosquitos lasted for at least 8 weeks, but not 16 weeks, after the last immunization with irradiated sporozoites. By contrast, volunteers who were exposed to a total of 200 or fewer irradiated infected mosquitos on 2-4 occasions were not protected upon challenge. Immunization by a sufficient number of irradiated mosquitos infected with the chloroquine-sensitive Tamenie strain from Ethiopia also protected against challenge with the chloroquine-resistant Marks strain of P. falciparum from Viet Nam. The results obtained in these studies suggest that immunization with attenuated sporozoites may be a useful method of protecting small groups of nonimmune individuals living in endemic areas. These findings should encourage further efforts to develop a sporozoite vaccine against human malaria." @default.
- W125201431 created "2016-06-24" @default.
- W125201431 creator A5003204240 @default.
- W125201431 creator A5006657863 @default.
- W125201431 creator A5090595018 @default.
- W125201431 creator A5091517194 @default.
- W125201431 date "1979-01-01" @default.
- W125201431 modified "2023-10-03" @default.
- W125201431 title "Use of attenuated sporozoites in the immunization of human volunteers against falciparum malaria." @default.
- W125201431 cites W1969660222 @default.
- W125201431 cites W2082008654 @default.
- W125201431 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2395727" @default.
- W125201431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/120773" @default.
- W125201431 hasPublicationYear "1979" @default.
- W125201431 type Work @default.
- W125201431 sameAs 125201431 @default.
- W125201431 citedByCount "65" @default.
- W125201431 countsByYear W1252014312012 @default.
- W125201431 countsByYear W1252014312013 @default.
- W125201431 countsByYear W1252014312014 @default.
- W125201431 countsByYear W1252014312015 @default.
- W125201431 countsByYear W1252014312016 @default.
- W125201431 countsByYear W1252014312017 @default.
- W125201431 countsByYear W1252014312018 @default.
- W125201431 countsByYear W1252014312019 @default.
- W125201431 countsByYear W1252014312021 @default.
- W125201431 countsByYear W1252014312022 @default.
- W125201431 crossrefType "journal-article" @default.
- W125201431 hasAuthorship W125201431A5003204240 @default.
- W125201431 hasAuthorship W125201431A5006657863 @default.
- W125201431 hasAuthorship W125201431A5090595018 @default.
- W125201431 hasAuthorship W125201431A5091517194 @default.
- W125201431 hasConcept C104317684 @default.
- W125201431 hasConcept C136264566 @default.
- W125201431 hasConcept C159047783 @default.
- W125201431 hasConcept C159654299 @default.
- W125201431 hasConcept C162324750 @default.
- W125201431 hasConcept C173758957 @default.
- W125201431 hasConcept C180032290 @default.
- W125201431 hasConcept C203014093 @default.
- W125201431 hasConcept C2777425658 @default.
- W125201431 hasConcept C2777775583 @default.
- W125201431 hasConcept C2778048844 @default.
- W125201431 hasConcept C2778371730 @default.
- W125201431 hasConcept C2780478335 @default.
- W125201431 hasConcept C2780801004 @default.
- W125201431 hasConcept C2781375639 @default.
- W125201431 hasConcept C3017753974 @default.
- W125201431 hasConcept C54602769 @default.
- W125201431 hasConcept C55493867 @default.
- W125201431 hasConcept C59822182 @default.
- W125201431 hasConcept C60987743 @default.
- W125201431 hasConcept C71924100 @default.
- W125201431 hasConcept C86803240 @default.
- W125201431 hasConceptScore W125201431C104317684 @default.
- W125201431 hasConceptScore W125201431C136264566 @default.
- W125201431 hasConceptScore W125201431C159047783 @default.
- W125201431 hasConceptScore W125201431C159654299 @default.
- W125201431 hasConceptScore W125201431C162324750 @default.
- W125201431 hasConceptScore W125201431C173758957 @default.
- W125201431 hasConceptScore W125201431C180032290 @default.
- W125201431 hasConceptScore W125201431C203014093 @default.
- W125201431 hasConceptScore W125201431C2777425658 @default.
- W125201431 hasConceptScore W125201431C2777775583 @default.
- W125201431 hasConceptScore W125201431C2778048844 @default.
- W125201431 hasConceptScore W125201431C2778371730 @default.
- W125201431 hasConceptScore W125201431C2780478335 @default.
- W125201431 hasConceptScore W125201431C2780801004 @default.
- W125201431 hasConceptScore W125201431C2781375639 @default.
- W125201431 hasConceptScore W125201431C3017753974 @default.
- W125201431 hasConceptScore W125201431C54602769 @default.
- W125201431 hasConceptScore W125201431C55493867 @default.
- W125201431 hasConceptScore W125201431C59822182 @default.
- W125201431 hasConceptScore W125201431C60987743 @default.
- W125201431 hasConceptScore W125201431C71924100 @default.
- W125201431 hasConceptScore W125201431C86803240 @default.
- W125201431 hasLocation W1252014311 @default.
- W125201431 hasOpenAccess W125201431 @default.
- W125201431 hasPrimaryLocation W1252014311 @default.
- W125201431 hasRelatedWork W125201431 @default.
- W125201431 hasRelatedWork W1561506538 @default.
- W125201431 hasRelatedWork W1970175579 @default.
- W125201431 hasRelatedWork W2081887587 @default.
- W125201431 hasRelatedWork W2133748715 @default.
- W125201431 hasRelatedWork W2400824973 @default.
- W125201431 hasRelatedWork W2551347115 @default.
- W125201431 hasRelatedWork W2902334063 @default.
- W125201431 hasRelatedWork W3195392879 @default.
- W125201431 hasRelatedWork W81419938 @default.
- W125201431 hasVolume "57 Suppl 1" @default.
- W125201431 isParatext "false" @default.
- W125201431 isRetracted "false" @default.
- W125201431 magId "125201431" @default.
- W125201431 workType "article" @default.