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- W1252651456 abstract "Publisher Summary This chapter explores the causes of the sexually transmitted infections like gonorrhea, nongonococcal urethritis, genital herpes virus infections, and trichomoniasis and their possible treatments. For the treatment of Neisseria gonorrhoeae, penicillin along with ampicillin and amoxicillin has been used with positive results. Several newer cephalosporins and cephamycins have been tested clinically in gonorrhea. Cefazolin, cefoxitin, cefuroxime, cefamandole, and others are effective in vitro , but have given variable results in clinical trials. Spectinomycin is the recommended treatment for gonorrhea that has not responded to a penicillin or tetracycline, as well as for patients with allergy or idiosyncratic intolerance to these agents. An important cause of the non-gonococcal urethritis (NGU) syndromes is plasma urealyticum (“T-strain mycoplasma”). The tetracyclines are the agents of choice for the treatment of NGU. Aminocyclitols in general and spectinomycin in particular, are effective in not more than half the patients with NGU. Sexually transmitted infections with Herpes simplex (Herpesvirus homnis) are compounded by its recurrent nature for its probable etiologic association with squamous cell carcinoma of the cervix, its association with infrequent but devastating neonatal infections, and the lack of effective prophylaxis or therapy. Several newer agents with antiviral activity are in various stages of testing in animal models and in clincial trials. Most promising, however, may be acycloguanosine and its triphosphate, that act by selectively inhibiting thymidine kinase to a greater degree in herpes-infected than in non-infected mammalian cells, potentially allowing for heretofore unrealized therapeutic ratios. Vaginitis because of the parasite Trichomonas vaginalis has been successfully treated for a long period of time with metronidazole in multiple dose regimens with cure rates of 90%-95% when male consorts were treated simultaneously." @default.
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- W1252651456 title "Chapter 12 Chemotherapy of Sexually Transmitted Infections" @default.
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