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- W125265939 abstract "Each year, 234 million major surgical procedures are performed worldwide. Despite the overall low risk of death and complications, there is a specific high-risk subgroup, representing over 80 % of postoperative deaths [1]. In the surgical population, poor outcome seems to be determined, among others, by derangements in global oxygen delivery (DO2) and oxygen consumption (VO2) derived by a complex interplay between surgical-induced inflammatory response and patient status [2, 3]. Systemic inflammatory response is associated with an increase in oxygen demand [4] that sometimes fails to be matched by an adequate increase of DO2 promoting hypoperfusion and tissue hypoxia. The consequences of tissue hypoxia are complicated and far reaching and include activation of endothelium, leading to capillary leak, and pro-inflammatory cytokines, leukocyte and complement cascade, enhancing inflammatory status. If this process is left unabated, postoperative complications, which are often fatal, may develop [5, 6]. The strategy of hemodynamic optimization or goal-directed therapy refers to the monitoring and manipulation of physiological hemodynamic parameters by means of therapeutic interventions based mainly on fluids, red blood cells (RBCs) and inotropic drugs aimed at facing the increase in oxygen demand.KeywordsPulmonary Artery Occlusion PressureDirected TherapyOxygen DebtHemodynamic OptimizationCanadian Critical Care Trial GroupThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W125265939 created "2016-06-24" @default.
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- W125265939 date "2011-01-01" @default.
- W125265939 modified "2023-09-25" @default.
- W125265939 title "Perioperative Hemodynamic Optimization" @default.
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- W125265939 doi "https://doi.org/10.1007/978-3-642-18081-1_42" @default.
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