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- W125280650 abstract "Abstract Previously, we reported that NKT cells play an important role in the development of Th1 responses and host resistance to Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS. In the present study, we addressed the role of dendritic cells (DCs) to activate mouse liver mononuclear cells (LMNCs), known as a rich source of NKT cells. LMNC were activated in response to C. neoformans-pulsed mouse bone marrow-derived dendritic cells (BMDCs) and produced IFN-γ, which was significantly suppressed by anti-CD1d antibody. This response was abrogated or reduced when BMDCs from CD1dKO or LMNCs from Jα18KO mice were used. In addition, NKT hybridoma cells were cultured on recombinant CD1d protein-coated plates with lipid from this fungal pathogen and IL-2 synthesis was measured. The total lipid led to their activation, although not profound in magnitude. These results suggest that DCs present some lipid antigen from C. neoformans in a CD1d-dependent manner for the activation of NKT cells." @default.
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- W125280650 date "2007-04-01" @default.
- W125280650 modified "2023-09-24" @default.
- W125280650 title "CD1d-dependent activation of NKT cells by <i>Cryptococcus neoformans</i>-pulsed dendritic cells (B172)" @default.
- W125280650 doi "https://doi.org/10.4049/jimmunol.178.supp.b172" @default.
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