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- W125302570 abstract "The molecular events responsible for the inhibition of cell proliferation by alpha-tocopherol have been investigated. Smooth muscle cells in vitro have been shown to be specifically inhibited by alpha-tocopherol with a concomitant inhibition of protein kinase C activity. beta-Tocopherol was inactive, despite its similar radical scavenging activity. The point of inhibition of alpha-tocopherol relative to the cell cycle was localized in the late G1 phase. A second effect of alpha-tocopherol observed with smooth muscle cells was the stimulation of protein kinase C biosynthesis in both the S and G2 phases of the cell cycle. The implications of these findings for the onset of arteriosclerosis are discussed." @default.
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- W125302570 date "1992-01-01" @default.
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- W125302570 title "Molecular basis of α-tocopherol inhibition of smooth muscle cell proliferation in vitro" @default.
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- W125302570 doi "https://doi.org/10.1007/978-3-0348-7460-1_17" @default.
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