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• W125307523 startingPage "237" @default.
• W125307523 abstract "After myocardial infarction (MI), the heart adapts to the loss of con tractile units by cardiac remodelling, a phenomenon which includes processes such as wound healing, ventricular dilatation and ventricular hypertrophy. The renin-angiotensin system (RAS) is a neurohormonal system that has been suggested to play an important role during cardiac remodelling after MI. Immediately after MI, the expression and activity of many RAS components are elevated, not only in the circulation, but also in the heart. Increased circulating angiotensin II will lead to increased vascular resistance, which supports arterial pressure in a situation of reduced cardiac output. Locally elevated angiotensin II is supposed to influence the processes of fibrosis and hypertrophy, because of its growth-promoting capacity. RAS activation is appropriate du ring the early cardiac adaptations after MI; however, prolonged act ivation could eventually worsen cardiac performance. High vascular resistance increases cardiac stroke work and augments oxygen consumption . Although new vessels emerge in th e noninfarcted myocardium, the capillary to myocyte-fibre ratio is decreased, as is oxygen availability. Hence, disproportionate hypertrophy decreases the capillary density even further and excessive fibrosis induces cardiac stiffness. By inhibiting the RAS activity, either via ACE inhibition or AT1 receptor antagonism, post-MI left ventricular dysfunction can be reduced, leading to a substantially higher rate of survival. These beneficial effects have been studied extensively but have, so far, not elucidated a uniform responsible mechanism. The exact roles of the AT2 receptor and the bradykinin type 2 receptor are still uncertain. The present review discusses the proposed contributions of the RAS in the process of post-MI cardiac remodelling" @default.
• W125307523 created "2016-06-24" @default.
• W125307523 creator A5035889183 @default.
• W125307523 creator A5056313715 @default.
• W125307523 creator A5058842094 @default.
• W125307523 date "2004-01-01" @default.
• W125307523 modified "2023-09-27" @default.
• W125307523 title "Activation of the Renin-Angiotensin System After Myocardial Infarction" @default.
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