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- W125428001 abstract "Recovery of endothelial integrity after vascular injury is vital for normal endothelial barrier function and vascular homeostasis. Our recent findings provided clear evidence of FoxM1 in regulation of endothelial cell proliferation and its critical role in endothelial repair following vascular injury (J. Clin. Invest. 2006, 116: –2343). To further investigate the mechanisms of FoxM1-mediated endothelial repair, we tested the hypothesis that FoxM1 regulates the reorganization of endothelial junctional complexes following vascular injury. Scanning electron microscopic analysis revealed leakage sites in the pulmonary microvessels with endothelial-restricted deficiency of FoxM1 48h post-LPS challenge, whereas the wild-type microvessels had completely repaired. Employing siRNA against human FoxM1, 90% of FoxM1 mRNA was knocked down in primary cultures of human pulmonary artery endothelial cells (HPAEC). Thrombin treatment resulted in similar degree of disruption of the endothelial monolayer barriers of FoxM1-deficient HPAEC and wild-type HPAEC as evident by the transendothelial monolayer electric resistance assay and immunofluorescence confocal microscopic analysis. However, FoxM1-deficiency impaired the recovery of endothelial monolayer barrier. Quantitative real time RT-PCR demonstrated significantly decreased expression of claudin-12 and β-catenin in FoxM1-deficient endothelial cells. Taken together, these data demonstrate that FoxM1 plays a critical role in the re-annealing of endothelial adherens and tight junctions during endothelial repair." @default.
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- W125428001 date "2007-01-01" @default.
- W125428001 modified "2023-09-27" @default.
- W125428001 title "FoxM1 Regulates Re‐annealing of Endothelial Junctions Following Vascular Injury" @default.
- W125428001 doi "https://doi.org/10.1096/fasebj.21.6.a860-c" @default.
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