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- W1258014610 abstract "The term granulation refers to a process of size-enlargement, whereby primary powder particles are gathered into larger, semi-permanent aggregates (granules) in which the original particles still can be identified. The main reasons for granulation in the pharmaceutical industry are to prevent segregation of the constituents of the powder mix and to improve the flow properties and compaction characteristics of the mix. The most commonly used techniques in the pharmaceutical industry for wet granulation are fluid bed granulation and high-shear granulation, which are batchwise production processes. In recent years, the development of continuous granulation processes has gained the interest in the pharmaceutical industry, due to the elimination of scale-up and the possibility of a 24h production line. Several continuous granulation processes are known, twin-screw extrusion is one of these techniques. At the Laboratory of Pharmaceutical Technology (Ghent University), a continuous twin-screw granulation process was developed by modifications to the extruder set-up and screw design, producing granules immediately suitable for tabletting.This aim of this thesis was the further development and evaluation of this continuous twin-screw granulation process." @default.
- W1258014610 created "2016-06-24" @default.
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- W1258014610 date "2009-01-01" @default.
- W1258014610 modified "2023-09-24" @default.
- W1258014610 title "Development and evaluation of a continuous granulation technique using a twin-screw extruder" @default.
- W1258014610 hasPublicationYear "2009" @default.
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