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- W125842905 abstract "Publisher Summary This chapter discusses biosynthesis, regulation, and genetics of macrolide production. Macrolide compounds refer to a class of natural products synthesized by bacteria, fungi, and plants through the successive condensation of simple short-chain fatty acids. They exhibit antibacterial, antifungal, antiparasite, insecticidal, antitumor activity, and immunosuppressive activity. They consist of polyketide-derived aglycons linked to saccharides and some macrolides contain only aglycons. The polyketides are generally classified into two major classes namely the aromatic and the complex polyketides. Aromatic polyketides are largely produced through the condensation of acetates, which generate β-keto groups that remain largely unreduced during and after initiation of the acyl chain. Complex polyketides are structurally more diverse than the aromatic polyketides and are composed of acetates, propionates, and butyrates in varying ratios. The biosynthetic mechanism for the formation of complex polyketides, represented by the aglycons of the various classes of macrolides, is different from that for the aromatic polyketides. Polyketide chains cyclize through lactonization to form aglycon rings. The chapter further deals with explanation of reaction mechanism of polyketide biosynthesis, genes encoding modular polyketide synthase, and sugar biosynthesis." @default.
- W125842905 created "2016-06-24" @default.
- W125842905 creator A5045164227 @default.
- W125842905 creator A5051175802 @default.
- W125842905 date "2003-01-01" @default.
- W125842905 modified "2023-10-18" @default.
- W125842905 title "Biosynthesis, Regulation, and Genetics of Macrolide Production" @default.
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