Matches in SemOpenAlex for { <https://semopenalex.org/work/W1258551370> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W1258551370 abstract "Exposure of human bronchial epithelial (HBE) cells from normal and asthmatic subjects to Alternaria alternata extract evoked rapid and sustained ATP release with greater efficacy observed in cells from asthmatic subjects. Previously, Alternaria aeroallergens were shown to elicit sustained increases in intracellular [Ca2+]i that depended on coordinated activation of P2Y2 and P2X7 receptors. In this study, pretreatment with BAPTA-AM inhibited ATP release, indicating dependency on increases in [Ca2+]i. Alternaria-evoked ATP release exhibited a greater peak response and higher EC50 value in cells obtained from asthmatic subjects compared to normal controls. Furthermore, the maximum increase in [Ca2+]i was greater in cells from asthmatic subjects. The vesicle transport inhibitor brefeldin A blocked Alternaria-stimulated incorporation of fluorescent lipid (FM1–43) labeled vesicles into the plasma membrane and ATP release. Additionally, inhibiting vesicular ATP uptake with bafilomycin also blocked ATP release similar to brefeldin A. These results indicated that a primary mechanism for Alternaria-induced ATP release involved Ca2+-dependent vesicular transport. Serine and cysteine protease inhibitors also reduced Alternaria-induced ATP release. This result was consistent with our previous data showing that Alternaria-evoked increases in [Ca2+]i depend on purinoceptor signaling." @default.
- W1258551370 created "2016-06-24" @default.
- W1258551370 creator A5015999967 @default.
- W1258551370 creator A5028434125 @default.
- W1258551370 creator A5043691460 @default.
- W1258551370 creator A5044155204 @default.
- W1258551370 creator A5046267434 @default.
- W1258551370 date "2013-04-01" @default.
- W1258551370 modified "2023-09-23" @default.
- W1258551370 title "Alternaria alternata aeroallergens evoke ATP release and IL‐33 secretion from normal and asthmatic bronchial epithelial cells." @default.
- W1258551370 doi "https://doi.org/10.1096/fasebj.27.1_supplement.1166.18" @default.
- W1258551370 hasPublicationYear "2013" @default.
- W1258551370 type Work @default.
- W1258551370 sameAs 1258551370 @default.
- W1258551370 citedByCount "0" @default.
- W1258551370 crossrefType "journal-article" @default.
- W1258551370 hasAuthorship W1258551370A5015999967 @default.
- W1258551370 hasAuthorship W1258551370A5028434125 @default.
- W1258551370 hasAuthorship W1258551370A5043691460 @default.
- W1258551370 hasAuthorship W1258551370A5044155204 @default.
- W1258551370 hasAuthorship W1258551370A5046267434 @default.
- W1258551370 hasConcept C119062480 @default.
- W1258551370 hasConcept C1491633281 @default.
- W1258551370 hasConcept C185592680 @default.
- W1258551370 hasConcept C190283241 @default.
- W1258551370 hasConcept C203522944 @default.
- W1258551370 hasConcept C2777722557 @default.
- W1258551370 hasConcept C2779771029 @default.
- W1258551370 hasConcept C2781373781 @default.
- W1258551370 hasConcept C49039625 @default.
- W1258551370 hasConcept C54355233 @default.
- W1258551370 hasConcept C55493867 @default.
- W1258551370 hasConcept C79879829 @default.
- W1258551370 hasConcept C86803240 @default.
- W1258551370 hasConceptScore W1258551370C119062480 @default.
- W1258551370 hasConceptScore W1258551370C1491633281 @default.
- W1258551370 hasConceptScore W1258551370C185592680 @default.
- W1258551370 hasConceptScore W1258551370C190283241 @default.
- W1258551370 hasConceptScore W1258551370C203522944 @default.
- W1258551370 hasConceptScore W1258551370C2777722557 @default.
- W1258551370 hasConceptScore W1258551370C2779771029 @default.
- W1258551370 hasConceptScore W1258551370C2781373781 @default.
- W1258551370 hasConceptScore W1258551370C49039625 @default.
- W1258551370 hasConceptScore W1258551370C54355233 @default.
- W1258551370 hasConceptScore W1258551370C55493867 @default.
- W1258551370 hasConceptScore W1258551370C79879829 @default.
- W1258551370 hasConceptScore W1258551370C86803240 @default.
- W1258551370 hasIssue "S1" @default.
- W1258551370 hasLocation W12585513701 @default.
- W1258551370 hasOpenAccess W1258551370 @default.
- W1258551370 hasPrimaryLocation W12585513701 @default.
- W1258551370 hasRelatedWork W1963661627 @default.
- W1258551370 hasRelatedWork W1971607044 @default.
- W1258551370 hasRelatedWork W1980218980 @default.
- W1258551370 hasRelatedWork W2007392433 @default.
- W1258551370 hasRelatedWork W2015604045 @default.
- W1258551370 hasRelatedWork W2033277975 @default.
- W1258551370 hasRelatedWork W2064756555 @default.
- W1258551370 hasRelatedWork W2163272425 @default.
- W1258551370 hasRelatedWork W3177711935 @default.
- W1258551370 hasRelatedWork W4231866301 @default.
- W1258551370 hasVolume "27" @default.
- W1258551370 isParatext "false" @default.
- W1258551370 isRetracted "false" @default.
- W1258551370 magId "1258551370" @default.
- W1258551370 workType "article" @default.