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- W1259016172 abstract "Sample complexity and dynamic range constitute enormous challenges in proteome analysis. The back-end technology in typical proteomics platforms, namely mass spectrometry (MS), can only tolerate a certain complexity, has a limited dynamic range per spectrum and is very sensitive towards ion suppression. Therefore, component overlap has to be minimized for successful mass spectrometric analysis and subsequent protein identification and quantification. The present review describes the advances that have been made in liquid-based separation techniques with focus on the recent developments to boost the resolving power. The review is divided in two parts; the first part deals with unidimensional liquid chromatography and the second part with bi- and multidimensional liquid-based separation techniques. Part 1 mainly focuses on reversed-phase HPLC due to the fact that it is and will, in the near future, remain the technique of choice to be hyphenated with MS. The impact of increasing the column length, decreasing the particle diameter, replacing the traditional packed beds by monolithics, amongst others, is described. The review is complemented with data obtained in the laboratories of the authors." @default.
- W1259016172 created "2016-06-24" @default.
- W1259016172 creator A5007419432 @default.
- W1259016172 creator A5009743996 @default.
- W1259016172 creator A5010949406 @default.
- W1259016172 creator A5044961801 @default.
- W1259016172 creator A5068403177 @default.
- W1259016172 creator A5077640750 @default.
- W1259016172 date "2008-04-01" @default.
- W1259016172 modified "2023-10-14" @default.
- W1259016172 title "Highly efficient peptide separations in proteomics" @default.
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