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- W125934385 abstract "Tumor suppressor protein p53 is a critical transcription factor involved in an intricate signaling network responsible for cell fate. In over half of all human cancers, p53 is found inactivated from missense mutations and is only marginally stable at physiological conditions. Therefore, immense research has become focused on stabilizing p53. This study intends to test two p53 mutants for relative stability based on prior computational predictions that involved a previously engineered ‘super-stable’ mutant and a simulated loop deletion mutant, which is predicted to be more stable. Based on protein purification observations for both mutants, significant differences in structural features seem apparent, even before detailed biophysical characterization. The significance of this study is twofold. First, this work may initiate similar studies to ultimately impact the reliability on computational predictions for molecular stability, possibly leading to a widespread use for high throughput analysis of biomolecules. Finally, we may be able to develop insight for additional stabilizing forces of p53 that may enhance therapeutic drug design for many cancer types." @default.
- W125934385 created "2016-06-24" @default.
- W125934385 creator A5055306066 @default.
- W125934385 date "2007-06-01" @default.
- W125934385 modified "2023-09-23" @default.
- W125934385 title "Improving Stability of Tumor Suppressor Protein, p53" @default.
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