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- W125941013 abstract "TGF-β has been implicated as an important factor in the growth, progression, and metastatic potential of advanced cancers. Increased expression and production of TGF-β has been found in many neoplasms, including prostate, breast, pancreatic, kidney, liver, colorectal, gastric, esophageal, ovarian, cervical, bladder, myeloma, head and neck, thyroid, Kaposi’s, melanoma, and non-small cell and small cell lung cancers and has been associated with significantly shorter patient survival. Elevated TGF-β may augment tumor growth by suppressing the immune system, stimulating neovascularization, mediating tumor/stromal interactions that stimulate tumor cell proliferation, and initiating epithelial-mesenchymal transition which may contribute to tumor metastasis. Antibodies neutralizing or blocking TGF-β may disrupt a key pathway that promotes tumor growth and provide an important therapeutic opportunity. Anti-TGF-β antibodies may become key components of therapeutic regimens when combined with standard radiation, hormonal, and/or chemotherapies. The ultimate safety and efficacy of TGF-β antagonists in the treatment of cancer will be established by clinical trials." @default.
- W125941013 created "2016-06-24" @default.
- W125941013 creator A5039385026 @default.
- W125941013 creator A5040137655 @default.
- W125941013 creator A5049247537 @default.
- W125941013 date "2008-01-01" @default.
- W125941013 modified "2023-10-17" @default.
- W125941013 title "Rationale for Anti-TGF-β Antibody Therapy in Oncology" @default.
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- W125941013 doi "https://doi.org/10.1007/978-1-59745-293-9_46" @default.
- W125941013 hasPublicationYear "2008" @default.
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