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- W1259658612 abstract "Publisher Summary During the past few years, considerable progress has been made toward the development of specific new methods for the analysis of steroid receptor concentrations in discrete, anatomically defined regions of the brain. These methods are based on two experimental approaches. The first method includes a variety of modifications of earlier subcellular fractionation-based steroid receptor assay procedures combined with the Palkovits microdissection method to achieve the necessary anatomical resolution. The second approach is based on quantitation of the uptake of radiolabeled steroids by the tissue through densitometric analysis of autoradiograms prepared by the exposure of tissue sections against film. This chapter outlines the principal features of these two methodological strategies: microchemical measurement of steroid receptors in the central nervous system (CNS) and quantitative autoradiography for the measurement of steroid receptor levels in the central nervous system. Measurement of steroid receptor levels in individual microdissected cell groups from the CNS, however, presents special technical problems that restrict the range of methodology that can be successfully applied. For more than two decades, the primary method for high-resolution localization of steroid binding sites in the brain has been autoradiography. Perhaps the most exciting potential application of these methods reviewed in the chapter is the possibility for integrating high-resolution measurements of steroid receptor levels with other biochemical and anatomical techniques. Using combinations of experimental approaches, it may be possible to achieve a far greater understanding of the mechanisms of steroid hormone action on the brain." @default.
- W1259658612 created "2016-06-24" @default.
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- W1259658612 date "1990-01-01" @default.
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- W1259658612 title "Autoradiographic and Microchemical Methods for Quantitation of Steroid Receptors" @default.
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- W1259658612 doi "https://doi.org/10.1016/b978-0-12-185255-9.50006-7" @default.
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