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- W1261163359 abstract "Tumors have developed different mechanisms to evade immune surveillance including alterations of classical and non-classical HLA class I antigens. The non-classical HLA-G antigen is often overexpressed in solid and hematopoietic tumors, thereby, creating a tolerogenic phenotype leading to an escape from T and NK cell-mediated immune responses by binding to the inhibitory receptors ILT2, ILT4 and KIR2DL4. Consequently, HLA-G+ tumors are associated with disease progression and in some cases with a poor clinical outcome of patients. Furthermore, high levels of soluble HLA-G have often been detected in serum, plasma and malignant ascites of tumor patients, which also correlated with a poor patients’ prognosis. Under physiologic conditions HLA-G expression is tightly controlled, limited to mainly immune privileged tissues/cells and could be regulated at the transcriptional, epigenetic as well as post-transcriptional levels. Recently, miRs regulating HLA-G expression have been identified, which could be used as tools for therapeutic intervention. Translational inhibition of HLA-G could reduce the immune escape of tumors, and increase the sensitivity to T cell- and/or NK cell-mediated cytotoxicity. However, the function of HLA-G expression is more complex, since next to trogocytosis a HLA-G-mediated inhibition of malignant hematopoietic cell proliferation was found mediated by an interaction of HLA-G with the ILT2 receptor involved in the negative signaling of B cell proliferation. Furthermore, HLA-G-regulating miRs also possess tumor suppressive activities by modulating apoptosis sensitivity and drug resistance. HLA-G exhibits a dual tumor type-dependent role by altering not only the immune surveillance, but rather also shaping the tumorigenic properties of tumor cells." @default.
- W1261163359 created "2016-06-24" @default.
- W1261163359 creator A5018687596 @default.
- W1261163359 creator A5029462216 @default.
- W1261163359 date "2015-01-01" @default.
- W1261163359 modified "2023-09-24" @default.
- W1261163359 title "Role of the Non-classical HLA Class I Antigens for Immune Escape" @default.
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- W1261163359 doi "https://doi.org/10.1007/978-3-319-17807-3_3" @default.
- W1261163359 hasPublicationYear "2015" @default.
- W1261163359 type Work @default.