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- W1261201829 abstract "4373 Hepatocellular carcinoma (HCC) is considered a solid tumor and is one of the ten most common human carcinomas in the world. Nuclear factor kappaB (NF-kappaB) is well described as a potent transcription factor that is involved in immunity and cancer cell survival. However, abnormal activation of NF-kappaB is linked with many types of diseases, including HCC. A recent study by Cusack and colleagues (2003) has shown that solid tumors expressing NF-kappaB can resist cell death. There are several risk factors for HCC including diabetes, smoking, chronic hepatitis B virus (HBV), alcoholism, aflatoxin, obesity and dietary carcinogen consumption. Our interest is in the dietary carcinogen 2-amino-3,8-dimethylimidazole [4,5,] quinoxaline (MeIQx). Previously our studies have shown that MeIQx can induce NF-kappaB in HepG2 cells. Since many studies have shown expression of the NF-kappaB regulated gene Bcl-3, we hypothesize that MeIQx can regulate the expression of Bcl-3 in hepatocellular carcinoma (HepG2) cells. We examined the effect of MeIQx exposure on Bcl-3 expression in HepG2 cells. Our studies indicate that MeIQx exposure regulated Bcl-3 expression in HepG2 cells in a time-dependent manner. These results support a model where HepG2 cells that are MeIQx stimulated can lead to cell death resistance and therefore cell survival. Supported in part by a Faculty Grant, Department of Biological Sciences,College of Arts and Sciences, NCAT State University(MHM), and Ohio Agricultural Research Development Center (OARDC, Seed grant),HATCH grant(USDA)(MHM)." @default.
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- W1261201829 date "2008-05-01" @default.
- W1261201829 modified "2023-09-26" @default.
- W1261201829 title "MeIQx regulates bcl-3 expression in human-derived hepatocellular carcinoma cells" @default.
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