Matches in SemOpenAlex for { <https://semopenalex.org/work/W1261262105> ?p ?o ?g. }
- W1261262105 endingPage "8191" @default.
- W1261262105 startingPage "8182" @default.
- W1261262105 abstract "The aim of the present study was to examine the role of Ganoderma atrum polysaccharide (PSG-1) in reactive oxygen species (ROS) generation and mitochondrial function in hyperglycemia-induced angiopathy. In this work, ROS scavenger, oxidizing agent tert-butylhydroperoxide (tBH), mitochondrial permeability transition pore (mPTP) blockers, and caspase inhibition are used to investigate whether PSG-1 may promote survival of human umbilical vein cells (HUVECs) through preventing the overproduction of ROS and mitochondrial dysfunction. Experimental results show that exposure of HUVECs to 35.5 mmol/L glucose increases the proportion of cells undergoing apoptosis. PSG-1, mPTP blocker, or caspase inhibition can reduce apoptosis and ROS generation. PSG-1 also increases mitochondrial Bcl-2 protein formation and mitochondrial membrane potential (ΔΨm) but inhibits Bax translocation, cytochrome c release, and caspase activation. In summary, vascular protection of PSG-1 can be mediated by a mitochondria-ROS pathway. ROS generation and mPTP induction are critical for high glucose-mediated apoptosis. PSG-1 ameliorates endothelial dysfunction by inhibiting oxidative stress and subsequent mitochondrial dysfunction." @default.
- W1261262105 created "2016-06-24" @default.
- W1261262105 creator A5014206663 @default.
- W1261262105 creator A5026570339 @default.
- W1261262105 creator A5039318925 @default.
- W1261262105 creator A5048412219 @default.
- W1261262105 creator A5051610166 @default.
- W1261262105 creator A5057756755 @default.
- W1261262105 creator A5066326611 @default.
- W1261262105 creator A5074169554 @default.
- W1261262105 creator A5075284628 @default.
- W1261262105 creator A5076120454 @default.
- W1261262105 date "2015-09-08" @default.
- W1261262105 modified "2023-10-14" @default.
- W1261262105 title "<i>Ganoderma atrum</i> Polysaccharide Ameliorates Hyperglycemia-Induced Endothelial Cell Death via a Mitochondria-ROS Pathway" @default.
- W1261262105 cites W1644794975 @default.
- W1261262105 cites W1964834484 @default.
- W1261262105 cites W1971210517 @default.
- W1261262105 cites W1973656650 @default.
- W1261262105 cites W1977248650 @default.
- W1261262105 cites W1980990984 @default.
- W1261262105 cites W1990768520 @default.
- W1261262105 cites W1992282049 @default.
- W1261262105 cites W1993039541 @default.
- W1261262105 cites W1994442108 @default.
- W1261262105 cites W1999745012 @default.
- W1261262105 cites W2009497505 @default.
- W1261262105 cites W2015879727 @default.
- W1261262105 cites W2024628230 @default.
- W1261262105 cites W2028107828 @default.
- W1261262105 cites W2032478715 @default.
- W1261262105 cites W2052017277 @default.
- W1261262105 cites W2059499269 @default.
- W1261262105 cites W2062120476 @default.
- W1261262105 cites W2071560305 @default.
- W1261262105 cites W2075443169 @default.
- W1261262105 cites W2086581233 @default.
- W1261262105 cites W2095703659 @default.
- W1261262105 cites W2098036900 @default.
- W1261262105 cites W2142713529 @default.
- W1261262105 cites W2142773795 @default.
- W1261262105 cites W2145388402 @default.
- W1261262105 cites W2146980664 @default.
- W1261262105 cites W2148230219 @default.
- W1261262105 cites W2150293050 @default.
- W1261262105 cites W2151943707 @default.
- W1261262105 cites W2159634370 @default.
- W1261262105 cites W2163301537 @default.
- W1261262105 cites W2165116045 @default.
- W1261262105 cites W2166566871 @default.
- W1261262105 cites W2321409785 @default.
- W1261262105 cites W2327027380 @default.
- W1261262105 cites W2331348076 @default.
- W1261262105 cites W2331400924 @default.
- W1261262105 cites W2332912296 @default.
- W1261262105 cites W4238598813 @default.
- W1261262105 doi "https://doi.org/10.1021/acs.jafc.5b03462" @default.
- W1261262105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26323486" @default.
- W1261262105 hasPublicationYear "2015" @default.
- W1261262105 type Work @default.
- W1261262105 sameAs 1261262105 @default.
- W1261262105 citedByCount "38" @default.
- W1261262105 countsByYear W12612621052016 @default.
- W1261262105 countsByYear W12612621052017 @default.
- W1261262105 countsByYear W12612621052018 @default.
- W1261262105 countsByYear W12612621052019 @default.
- W1261262105 countsByYear W12612621052020 @default.
- W1261262105 countsByYear W12612621052021 @default.
- W1261262105 countsByYear W12612621052022 @default.
- W1261262105 countsByYear W12612621052023 @default.
- W1261262105 crossrefType "journal-article" @default.
- W1261262105 hasAuthorship W1261262105A5014206663 @default.
- W1261262105 hasAuthorship W1261262105A5026570339 @default.
- W1261262105 hasAuthorship W1261262105A5039318925 @default.
- W1261262105 hasAuthorship W1261262105A5048412219 @default.
- W1261262105 hasAuthorship W1261262105A5051610166 @default.
- W1261262105 hasAuthorship W1261262105A5057756755 @default.
- W1261262105 hasAuthorship W1261262105A5066326611 @default.
- W1261262105 hasAuthorship W1261262105A5074169554 @default.
- W1261262105 hasAuthorship W1261262105A5075284628 @default.
- W1261262105 hasAuthorship W1261262105A5076120454 @default.
- W1261262105 hasConcept C134018914 @default.
- W1261262105 hasConcept C13591479 @default.
- W1261262105 hasConcept C137183658 @default.
- W1261262105 hasConcept C185592680 @default.
- W1261262105 hasConcept C190283241 @default.
- W1261262105 hasConcept C202751555 @default.
- W1261262105 hasConcept C2776151105 @default.
- W1261262105 hasConcept C2777411675 @default.
- W1261262105 hasConcept C2778175917 @default.
- W1261262105 hasConcept C2778674702 @default.
- W1261262105 hasConcept C28859421 @default.
- W1261262105 hasConcept C29311851 @default.
- W1261262105 hasConcept C31573885 @default.
- W1261262105 hasConcept C48349386 @default.
- W1261262105 hasConcept C513476851 @default.
- W1261262105 hasConcept C55493867 @default.
- W1261262105 hasConcept C86803240 @default.