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- W126203366 abstract "Practitioners are increasingly presented with data procured from studies employing advanced neuroimaging techniques. The central role that neuroimaging occupies in contemporary psychiatric research highlights the need for practitioner familiarity with the neuroimaging technology and its clinical translation.We conducted a PubMed search of all English-language articles published between January 1964 - October 2005. The search words were major depressive disorder, bipolar disorder, functional magnetic resonance imaging (fMRI), single-photon-emission computed tomography (SPECT), positron emission tomography (PET), voxel-based morphometry (VBM), region of interest (ROI), blood-oxygen-level-dependent (BOLD), glucose metabolism, blood flow, statistical parametric mapping (SPM), magnetic resonance spectroscopy (MRS), and diffusion-tensor imaging (DTI). The search was supplemented with a manual review of relevant references. The authors organize the review by addressing frequently asked questions on the topic of neuroimaging by mental healthcare providers.The localization of regional brain volumetric abnormalities with CT is enhanced with MRI techniques that allow for a separate assay of white and gray matter pathology (segmentation), cellular metabolism (MRS), and neurocircuitry (DTI). Positron emission tomography permits the quantification of brain glucose metabolism, regional blood flow, and receptor/transporter localization and function. Rapid changes in regional oxygen consumption may also be quantified with fMRI.Neuroimaging technology has helped refine pathophysiological models of disease activity in mood disorders and illuminate mechanisms of drug activity. A priority research vista in mood disorders is the integration of neuroimaging investigations with other research methods (e.g., genetics, endocrinology, etc.)." @default.
- W126203366 created "2016-06-24" @default.
- W126203366 creator A5019012235 @default.
- W126203366 creator A5032497184 @default.
- W126203366 creator A5041759678 @default.
- W126203366 creator A5047679191 @default.
- W126203366 creator A5068850044 @default.
- W126203366 date "2006-02-01" @default.
- W126203366 modified "2023-09-23" @default.
- W126203366 title "Clinical translation of neuroimaging research in mood disorders." @default.
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