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- W1262221686 startingPage "415" @default.
- W1262221686 abstract "Pluripotent stem cells have the capability to undergo unlimited self-renewal and differentiation into all somatic cell types. They have acquired specific adjustments in the cell cycle structure that allow them to rapidly proliferate, including cell cycle independent expression of cell cycle regulators and lax G1 to S phase transition. However, due to the developmental role of embryonic stem cells (ES) it is essential to maintain genomic integrity and prevent acquisition of mutations that would be transmitted to multiple cell lineages. Several modifications in DNA damage response of ES cells accommodate dynamic cycling and preservation of genetic information. The absence of a G1/S cell cycle arrest promotes apoptotic response of damaged cells before DNA changes can be fixed in the form of mutation during the S phase, while G2/M cell cycle arrest allows repair of damaged DNA following replication. Furthermore, ES cells express higher level of DNA repair proteins, and exhibit enhanced repair of multiple types of DNA damage. Similarly to ES cells, induced pluripotent stem (iPS) cells are poised to proliferate and exhibit lack of G1/S cell cycle arrest, extreme sensitivity to DNA damage, and high level of expression of DNA repair genes. The fundamental mechanisms by which the cell cycle regulates genomic integrity in ES cells and iPS cells are similar, though not identical." @default.
- W1262221686 created "2016-06-24" @default.
- W1262221686 creator A5028371146 @default.
- W1262221686 creator A5060338506 @default.
- W1262221686 creator A5087262757 @default.
- W1262221686 date "2011-01-01" @default.
- W1262221686 modified "2023-09-23" @default.
- W1262221686 title "Cell Cycle Adaptations and Maintenance of Genomic Integrity in Embryonic Stem Cells and Induced Pluripotent Stem Cells" @default.
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