Matches in SemOpenAlex for { <https://semopenalex.org/work/W1262479093> ?p ?o ?g. }
- W1262479093 endingPage "323" @default.
- W1262479093 startingPage "309" @default.
- W1262479093 abstract "A central issue in developing therapies for neurodegenerative diseases involves understanding why adaptive responses to stress or injury fail to prevent synaptic dysfunction and neuronal cell death. Macroautophagy is a major, evolutionarily conserved response to nutrient and bioenergetic stresses, which has the capacity to remove aggregated proteins and damaged organelles such as mitochondria. This has prompted intense interest in autophagy-related therapies for Huntington’s, Alzheimer’s, Parkinson’s, stroke and other neurological diseases. However, excessive or imbalanced induction of autophagic recycling can actively contribute to neuronal atrophy, neurite degeneration and cell death. Oxidative-, aging- and disease-related increases in demand for autophagy, coupled with declining axonal trafficking, lysosomal degradation or biosynthetic efficiencies promote increased susceptibility to a harmful state of autophagic stress. A more complete understanding of dysfunction along the entire spectrum of autophagic recycling, from autophagosome formation through clearance and regeneration of new cellular components, is necessary to restore balance to the system, promote neuronal health and maximize therapeutic potentials." @default.
- W1262479093 created "2016-06-24" @default.
- W1262479093 creator A5015453195 @default.
- W1262479093 creator A5060252949 @default.
- W1262479093 date "2008-05-01" @default.
- W1262479093 modified "2023-10-15" @default.
- W1262479093 title "Autophagy in neuroprotection and neurodegeneration: a question of balance" @default.
- W1262479093 cites W1507379002 @default.
- W1262479093 cites W1523693806 @default.
- W1262479093 cites W1523840486 @default.
- W1262479093 cites W1526993239 @default.
- W1262479093 cites W1641175229 @default.
- W1262479093 cites W1919353 @default.
- W1262479093 cites W1963579854 @default.
- W1262479093 cites W1967809393 @default.
- W1262479093 cites W1968016394 @default.
- W1262479093 cites W1969342645 @default.
- W1262479093 cites W1972336737 @default.
- W1262479093 cites W1976761774 @default.
- W1262479093 cites W1977645267 @default.
- W1262479093 cites W1980825524 @default.
- W1262479093 cites W1985028337 @default.
- W1262479093 cites W1985158738 @default.
- W1262479093 cites W1985628817 @default.
- W1262479093 cites W1986120117 @default.
- W1262479093 cites W1986711217 @default.
- W1262479093 cites W1988044873 @default.
- W1262479093 cites W1991075835 @default.
- W1262479093 cites W1991756308 @default.
- W1262479093 cites W1993772997 @default.
- W1262479093 cites W1994305081 @default.
- W1262479093 cites W1998121259 @default.
- W1262479093 cites W1999083701 @default.
- W1262479093 cites W2000936337 @default.
- W1262479093 cites W2002287054 @default.
- W1262479093 cites W2003887174 @default.
- W1262479093 cites W2005036104 @default.
- W1262479093 cites W2005144914 @default.
- W1262479093 cites W2006232414 @default.
- W1262479093 cites W2014918593 @default.
- W1262479093 cites W2016365088 @default.
- W1262479093 cites W2022812113 @default.
- W1262479093 cites W2023338943 @default.
- W1262479093 cites W2027417884 @default.
- W1262479093 cites W2030667534 @default.
- W1262479093 cites W2032377673 @default.
- W1262479093 cites W2032488669 @default.
- W1262479093 cites W2034132952 @default.
- W1262479093 cites W2037100007 @default.
- W1262479093 cites W2039474189 @default.
- W1262479093 cites W2040157483 @default.
- W1262479093 cites W2040826935 @default.
- W1262479093 cites W2041255615 @default.
- W1262479093 cites W2043377363 @default.
- W1262479093 cites W2047690887 @default.
- W1262479093 cites W2049613365 @default.
- W1262479093 cites W2052101545 @default.
- W1262479093 cites W2054595666 @default.
- W1262479093 cites W2055798927 @default.
- W1262479093 cites W2056367295 @default.
- W1262479093 cites W2056663185 @default.
- W1262479093 cites W2060579362 @default.
- W1262479093 cites W2062585755 @default.
- W1262479093 cites W2063691589 @default.
- W1262479093 cites W2065247147 @default.
- W1262479093 cites W2068213179 @default.
- W1262479093 cites W2070041362 @default.
- W1262479093 cites W2075088486 @default.
- W1262479093 cites W2078018384 @default.
- W1262479093 cites W2079046408 @default.
- W1262479093 cites W2080190164 @default.
- W1262479093 cites W2082229119 @default.
- W1262479093 cites W2082796078 @default.
- W1262479093 cites W2087360216 @default.
- W1262479093 cites W2090941537 @default.
- W1262479093 cites W2097631517 @default.
- W1262479093 cites W2097965815 @default.
- W1262479093 cites W2102356985 @default.
- W1262479093 cites W2103275390 @default.
- W1262479093 cites W2103377481 @default.
- W1262479093 cites W2108196410 @default.
- W1262479093 cites W2110084716 @default.
- W1262479093 cites W2111567059 @default.
- W1262479093 cites W2114806766 @default.
- W1262479093 cites W2116650656 @default.
- W1262479093 cites W2117155268 @default.
- W1262479093 cites W2117875646 @default.
- W1262479093 cites W2118898883 @default.
- W1262479093 cites W2119399459 @default.
- W1262479093 cites W2120640283 @default.
- W1262479093 cites W2128537698 @default.
- W1262479093 cites W2129023888 @default.
- W1262479093 cites W2130498948 @default.
- W1262479093 cites W2131155959 @default.
- W1262479093 cites W2135574023 @default.
- W1262479093 cites W2136709809 @default.
- W1262479093 cites W2139285220 @default.
- W1262479093 cites W2141732008 @default.