Matches in SemOpenAlex for { <https://semopenalex.org/work/W126330640> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W126330640 endingPage "72" @default.
- W126330640 startingPage "1268" @default.
- W126330640 abstract "The effects of the novel, 1,4-dihydropyridine derivative methyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) -pyridine-5-carboxylate (Bay k 8644) are reported. In contrast to the nifedipine-like dihydropyridines, which have calcium antagonistic actions. Bay k 8644 has positive inotropic and vasoconstrictor effects. The effects and mechanism of action of Bay k 8644 have been examined in the anaesthetised dog, on the isolated perfused guinea-pig heart, and on the isolated rabbit aortic strip. In these preparations Bay k 8644 is active in the same dose range as nifedipine, but has effects diametrically opposite to those of nifedipine. There is a competitive antagonism between Bay k 8644 and nifedipine, whereas verapamil and diltiazem produce only a functional, non-competitive inhibition of the effects of Bay k 8644. We conclude that a specific dihydropyridine receptor exists, which may bind both nifedipine and Bay k 8644. In contrast to nifedipine Bay k 8644 stimulates the calcium influx into the cell." @default.
- W126330640 created "2016-06-24" @default.
- W126330640 creator A5023874489 @default.
- W126330640 creator A5040423238 @default.
- W126330640 creator A5053194963 @default.
- W126330640 creator A5080586810 @default.
- W126330640 date "1983-01-01" @default.
- W126330640 modified "2023-10-01" @default.
- W126330640 title "Activation of calcium channels by novel 1,4-dihydropyridines. A new mechanism for positive inotropics or smooth muscle stimulants." @default.
- W126330640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6196037" @default.
- W126330640 hasPublicationYear "1983" @default.
- W126330640 type Work @default.
- W126330640 sameAs 126330640 @default.
- W126330640 citedByCount "66" @default.
- W126330640 countsByYear W1263306402023 @default.
- W126330640 crossrefType "journal-article" @default.
- W126330640 hasAuthorship W126330640A5023874489 @default.
- W126330640 hasAuthorship W126330640A5040423238 @default.
- W126330640 hasAuthorship W126330640A5053194963 @default.
- W126330640 hasAuthorship W126330640A5080586810 @default.
- W126330640 hasConcept C126322002 @default.
- W126330640 hasConcept C185592680 @default.
- W126330640 hasConcept C18699975 @default.
- W126330640 hasConcept C202751555 @default.
- W126330640 hasConcept C2776120743 @default.
- W126330640 hasConcept C2776741139 @default.
- W126330640 hasConcept C2777022698 @default.
- W126330640 hasConcept C2777294900 @default.
- W126330640 hasConcept C2779066535 @default.
- W126330640 hasConcept C2781212610 @default.
- W126330640 hasConcept C519063684 @default.
- W126330640 hasConcept C55493867 @default.
- W126330640 hasConcept C71924100 @default.
- W126330640 hasConcept C98274493 @default.
- W126330640 hasConceptScore W126330640C126322002 @default.
- W126330640 hasConceptScore W126330640C185592680 @default.
- W126330640 hasConceptScore W126330640C18699975 @default.
- W126330640 hasConceptScore W126330640C202751555 @default.
- W126330640 hasConceptScore W126330640C2776120743 @default.
- W126330640 hasConceptScore W126330640C2776741139 @default.
- W126330640 hasConceptScore W126330640C2777022698 @default.
- W126330640 hasConceptScore W126330640C2777294900 @default.
- W126330640 hasConceptScore W126330640C2779066535 @default.
- W126330640 hasConceptScore W126330640C2781212610 @default.
- W126330640 hasConceptScore W126330640C519063684 @default.
- W126330640 hasConceptScore W126330640C55493867 @default.
- W126330640 hasConceptScore W126330640C71924100 @default.
- W126330640 hasConceptScore W126330640C98274493 @default.
- W126330640 hasIssue "9" @default.
- W126330640 hasLocation W1263306401 @default.
- W126330640 hasOpenAccess W126330640 @default.
- W126330640 hasPrimaryLocation W1263306401 @default.
- W126330640 hasRelatedWork W126330640 @default.
- W126330640 hasRelatedWork W1965692949 @default.
- W126330640 hasRelatedWork W1969212993 @default.
- W126330640 hasRelatedWork W1978759282 @default.
- W126330640 hasRelatedWork W2016271841 @default.
- W126330640 hasRelatedWork W2049790783 @default.
- W126330640 hasRelatedWork W2062950741 @default.
- W126330640 hasRelatedWork W2091837568 @default.
- W126330640 hasRelatedWork W2129039306 @default.
- W126330640 hasRelatedWork W2148282970 @default.
- W126330640 hasVolume "33" @default.
- W126330640 isParatext "false" @default.
- W126330640 isRetracted "false" @default.
- W126330640 magId "126330640" @default.
- W126330640 workType "article" @default.