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• W126369564 abstract "Research Article1 October 1991free access Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease. R. Jakes R. Jakes MRC Laboratory of Molecular Biology, Cambridge. Search for more papers by this author M. Novak M. Novak MRC Laboratory of Molecular Biology, Cambridge. Search for more papers by this author M. Davison M. Davison MRC Laboratory of Molecular Biology, Cambridge. Search for more papers by this author C.M. Wischik C.M. Wischik MRC Laboratory of Molecular Biology, Cambridge. Search for more papers by this author R. Jakes R. Jakes MRC Laboratory of Molecular Biology, Cambridge. Search for more papers by this author M. Novak M. Novak MRC Laboratory of Molecular Biology, Cambridge. Search for more papers by this author M. Davison M. Davison MRC Laboratory of Molecular Biology, Cambridge. Search for more papers by this author C.M. Wischik C.M. Wischik MRC Laboratory of Molecular Biology, Cambridge. Search for more papers by this author Author Information R. Jakes1, M. Novak1, M. Davison1 and C.M. Wischik1 1MRC Laboratory of Molecular Biology, Cambridge. The EMBO Journal (1991)10:2725-2729https://doi.org/10.1002/j.1460-2075.1991.tb07820.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The microtubule associated protein tau is incorporated into the pronase resistant core of the paired helical filament (PHF) in such a way that the repeat region is protected from proteases, but can be released as a major 12 kDa species from the PHF core by formic acid treatment and by boiling in SDS. This fragment retains the ability to aggregate in the presence of SDS. Detailed sequence analysis of the 12 kDa species shows that it consists of a mixture of peptides derived from the repeat region of 3- and 4-repeat tau isoforms comigrating as a single electrophoretic band. However, the 4-repeat isoforms released from the core lack either the first or the last repeat. The pronase-protected region of tau within the PHF core is therefore restricted to three repeats, regardless of isoform. The alignment of cleavage sites at homologous positions within tandem repeats after protease treatment indicates that the tau-core association is precisely constrained by the tandem repeat structure of the tau molecule. Previous ArticleNext Article Volume 10Issue 101 October 1991In this issue RelatedDetailsLoading ..." @default.
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• W126369564 title "Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease." @default.
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