FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1263826191> ?p ?o ?g. }

• W1263826191 endingPage "IN12" @default.
• W1263826191 startingPage "915" @default.
• W1263826191 abstract "The prognosis of patients suffering from pancreatic cancer is still poor and novel therapeutic options are urgently needed. Recently, the transcription factor signal transducer and activator of transcription 5b (STAT5b) was associated with tumor progression in human solid cancer. Hence, we assessed whether STAT5b might serve as an anticancer target in ductal pancreatic adenocarcinoma (DPAC). We found that nuclear expression of STAT5b can be detected in approximately 50% of DPAC. Blockade of STAT5b by stable shRNA-mediated knockdown showed no effects on tumor cell growth in vitro. However, inhibition of tumor cell motility was found even in response to stimulation with epidermal growth factor or interleukin-6. These findings were paralleled by a reduction of prometastatic and proangiogenic factors in vitro. Subsequent in vivo experiments revealed a strong growth inhibition on STAT5b blockade in subcutaneous and orthotopic models. These findings were paralleled by impaired tumor angiogenesis in vivo. In contrast to the subcutaneous model, the orthotopic model revealed a strong reduction of tumor cell proliferation that emphasizes the meaning of assessing targets in an appropriate microenvironment. Taken together, our results suggest that STAT5b might be a potential novel target for human DPAC." @default.
• W1263826191 created "2016-06-24" @default.
• W1263826191 creator A5000905362 @default.
• W1263826191 creator A5005650529 @default.
• W1263826191 creator A5007121961 @default.
• W1263826191 creator A5015979307 @default.
• W1263826191 creator A5016783165 @default.
• W1263826191 creator A5024998614 @default.
• W1263826191 creator A5033468379 @default.
• W1263826191 creator A5043305493 @default.
• W1263826191 creator A5057974025 @default.
• W1263826191 creator A5071973338 @default.
• W1263826191 creator A5085774397 @default.
• W1263826191 creator A5087276676 @default.
• W1263826191 creator A5089659190 @default.
• W1263826191 date "2012-10-01" @default.
• W1263826191 modified "2023-10-16" @default.
• W1263826191 title "STAT5b as Molecular Target in Pancreatic Cancer—Inhibition of Tumor Growth, Angiogenesis, and Metastases" @default.
• W1263826191 cites W1525488085 @default.
• W1263826191 cites W1548640328 @default.
• W1263826191 cites W1985804036 @default.
• W1263826191 cites W1989563651 @default.
• W1263826191 cites W1990148312 @default.
• W1263826191 cites W1993307471 @default.
• W1263826191 cites W1996222406 @default.
• W1263826191 cites W1999060978 @default.
• W1263826191 cites W2013288089 @default.
• W1263826191 cites W2020894510 @default.
• W1263826191 cites W2027532379 @default.
• W1263826191 cites W2027773493 @default.
• W1263826191 cites W2048967458 @default.
• W1263826191 cites W2055479791 @default.
• W1263826191 cites W2070859603 @default.
• W1263826191 cites W2072826420 @default.
• W1263826191 cites W2078558213 @default.
• W1263826191 cites W2081994535 @default.
• W1263826191 cites W2096579084 @default.
• W1263826191 cites W2101425659 @default.
• W1263826191 cites W2101995865 @default.
• W1263826191 cites W2107441200 @default.
• W1263826191 cites W2112474929 @default.
• W1263826191 cites W2119394260 @default.
• W1263826191 cites W2124143152 @default.
• W1263826191 cites W2128071596 @default.
• W1263826191 cites W2132956465 @default.
• W1263826191 cites W2137725693 @default.
• W1263826191 cites W2140177229 @default.
• W1263826191 cites W2144683720 @default.
• W1263826191 cites W2151253787 @default.
• W1263826191 cites W2152392253 @default.
• W1263826191 cites W2157310617 @default.
• W1263826191 cites W2164562068 @default.
• W1263826191 cites W2169959879 @default.
• W1263826191 cites W2170189698 @default.
• W1263826191 cites W2312247216 @default.
• W1263826191 cites W4211208840 @default.
• W1263826191 cites W4236953012 @default.
• W1263826191 cites W4252559930 @default.
• W1263826191 doi "https://doi.org/10.1593/neo.12878" @default.
• W1263826191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3479837" @default.
• W1263826191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23097626" @default.
• W1263826191 hasPublicationYear "2012" @default.
• W1263826191 type Work @default.
• W1263826191 sameAs 1263826191 @default.
• W1263826191 citedByCount "29" @default.
• W1263826191 countsByYear W12638261912012 @default.
• W1263826191 countsByYear W12638261912013 @default.
• W1263826191 countsByYear W12638261912014 @default.
• W1263826191 countsByYear W12638261912015 @default.
• W1263826191 countsByYear W12638261912016 @default.
• W1263826191 countsByYear W12638261912017 @default.
• W1263826191 countsByYear W12638261912018 @default.
• W1263826191 countsByYear W12638261912019 @default.
• W1263826191 countsByYear W12638261912020 @default.
• W1263826191 countsByYear W12638261912021 @default.
• W1263826191 countsByYear W12638261912023 @default.
• W1263826191 crossrefType "journal-article" @default.
• W1263826191 hasAuthorship W1263826191A5000905362 @default.
• W1263826191 hasAuthorship W1263826191A5005650529 @default.
• W1263826191 hasAuthorship W1263826191A5007121961 @default.
• W1263826191 hasAuthorship W1263826191A5015979307 @default.
• W1263826191 hasAuthorship W1263826191A5016783165 @default.
• W1263826191 hasAuthorship W1263826191A5024998614 @default.
• W1263826191 hasAuthorship W1263826191A5033468379 @default.
• W1263826191 hasAuthorship W1263826191A5043305493 @default.
• W1263826191 hasAuthorship W1263826191A5057974025 @default.
• W1263826191 hasAuthorship W1263826191A5071973338 @default.
• W1263826191 hasAuthorship W1263826191A5085774397 @default.
• W1263826191 hasAuthorship W1263826191A5087276676 @default.
• W1263826191 hasAuthorship W1263826191A5089659190 @default.
• W1263826191 hasBestOaLocation W12638261911 @default.
• W1263826191 hasConcept C104317684 @default.
• W1263826191 hasConcept C121608353 @default.
• W1263826191 hasConcept C126322002 @default.
• W1263826191 hasConcept C150903083 @default.
• W1263826191 hasConcept C171958077 @default.
• W1263826191 hasConcept C173396325 @default.
• W1263826191 hasConcept C207001950 @default.

• next