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- W126593552 abstract "OBJECTIVE: The present study aimed at determining how 3-weeks intraperitoneal melatonin administration affected oxidative stress caused by experimental hyperthyroidism. MATERIALS AND METHODS: The study was conducted on 30 male rats of Spraque-Dawley species. The experimental animals were divided to 3 groups (control, hyperthyroidism and hyperthyroidism+melatonin). The supplementation was continued for 3 weeks after which the animals were sacrified and tissue malondyaldehyde (MDA) and glutathione (GSH) levels were determined. RESULTS: MDA levels in kidney and testis tissues in hyperthyroidism group were higher than those in control and hyperthyroidism+melatonin administered groups (p<0.001) and levels in hyperthyroidism + melatonin administered group were higher than those in the control group (p<0.001). The highest GSH levels were obtained in hyperthyroidism + melatonin-administered group (p<0.001) and GSH levels in hyperthyroidism group were higher than those in the control group (p<0.001). CONCLUSION: Results of the study demonstrate that hyperthyroidism induced by 3-weeks L-thyroxine administration increased oxidative stress in kidney and testis tissues and that although melatonin administration inhibited this stress to a certain extent, it could not bring the stress down to the level in controls." @default.
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- W126593552 date "2005-12-01" @default.
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- W126593552 title "Hyperthyroidism causes lipid peroxidation in kidney and testis tissues of rats: protective role of melatonin." @default.
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