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- W1266804984 abstract "Publisher Summary This chapter reviews the progress, which has been made in understanding how one particular cell system, the salivary gland of an insect, receives a chemical stimulus and translates the information into a change in activity. Comparison of the mode of action of 5-HT in Calliphora salivary glands with that of many other hormones reveals numerous similarities. External chemical stimuli responsible for regulating cellular activity may thus share a common mode of action. The various differences which are apparent today may represent modification of this basic mechanism developed during the course of evolution to adapt cells systems to new environments. The main feature of this control system concerns the transduction of hormonal information arriving at the cell into internal chemical signals, which can be recognized by the various effector mechanisms responsible for carrying out the actions of the hormone. In the original cyclic AMP-hypothesis, the hormonal signal input was transduced into cyclic AMP through an activation of the membrane-bound enzyme adenyl cyclase and cyclic AMP alone then mediated all further cellular events. The current hypothesis proposed by Rasmussen (1970) and verified in these salivary gland studies is that the conformational changes induced in the membrane by successful hormone-receptor interactions can be transduced into more than one secondary message." @default.
- W1266804984 created "2016-06-24" @default.
- W1266804984 creator A5022472681 @default.
- W1266804984 creator A5078013249 @default.
- W1266804984 date "1972-01-01" @default.
- W1266804984 modified "2023-10-18" @default.
- W1266804984 title "The Role of Cyclic AMP and Calcium in Hormone Action" @default.
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