Matches in SemOpenAlex for { <https://semopenalex.org/work/W126688401> ?p ?o ?g. }
- W126688401 endingPage "442" @default.
- W126688401 startingPage "409" @default.
- W126688401 abstract "In 1883, Sidney Ringer described the importance of calcium in cardiac contraction (Ringer, 1883). Since that seminal observation, the importance of calcium as a transducer for coupling of biological signals has become evident. The signal transduction role of calcium is made possible by a large, inward-directed gradient of ionized calcium across the plasma membrane. Cytosolic concentrations of calcium in a resting, nonstimulated cell are some 10,000-fold lower than external concentrations (approximately 10−7 M vs 10−3 M) (Fozzard et al., 1985; Tsien et al., 1984). This extreme gradient is maintained by an intrinsic low permeability of the plasma membrane to calcium, active exchange mechanisms and pumps that remove calcium, sequestration of calcium by intracellular organelles such as mitochondria and the endoplasmic reticulum, and buffering by cytosolic calcium-binding proteins. Elevation of cytosolic calcium contractions to 1–10 μM initiates physiologic responses appropriate to the cell type. In muscle, interaction with troponin C or other calcium-binding regulatory proteins initiates contraction. In neuronal, exocrine, and endocrine tissue, secretion ensues. The diversity of responses initiated, the energy expenditure to maintain low cytosolic levels, and the multiplicity of ways to deplete cytosolic calcium all highlight the biologic importance of this messenger system." @default.
- W126688401 created "2016-06-24" @default.
- W126688401 creator A5001958946 @default.
- W126688401 date "1987-01-01" @default.
- W126688401 modified "2023-09-27" @default.
- W126688401 title "Calcium Channel Antagonists" @default.
- W126688401 cites W1836994250 @default.
- W126688401 cites W1844605916 @default.
- W126688401 cites W1888388363 @default.
- W126688401 cites W1908071549 @default.
- W126688401 cites W1964951153 @default.
- W126688401 cites W1968612583 @default.
- W126688401 cites W1970814820 @default.
- W126688401 cites W1973285934 @default.
- W126688401 cites W1974167189 @default.
- W126688401 cites W1975869077 @default.
- W126688401 cites W1976103658 @default.
- W126688401 cites W1976846700 @default.
- W126688401 cites W1978322781 @default.
- W126688401 cites W1981457682 @default.
- W126688401 cites W1981718850 @default.
- W126688401 cites W1985663765 @default.
- W126688401 cites W1987013129 @default.
- W126688401 cites W1988433100 @default.
- W126688401 cites W1991516364 @default.
- W126688401 cites W1992130519 @default.
- W126688401 cites W1992188204 @default.
- W126688401 cites W1992941083 @default.
- W126688401 cites W1994600083 @default.
- W126688401 cites W1994924034 @default.
- W126688401 cites W1995437073 @default.
- W126688401 cites W1996940087 @default.
- W126688401 cites W1999179356 @default.
- W126688401 cites W1999701858 @default.
- W126688401 cites W1999922361 @default.
- W126688401 cites W2000938959 @default.
- W126688401 cites W2004117883 @default.
- W126688401 cites W2004264938 @default.
- W126688401 cites W2004534686 @default.
- W126688401 cites W2006038658 @default.
- W126688401 cites W2008205096 @default.
- W126688401 cites W2010813263 @default.
- W126688401 cites W2010976666 @default.
- W126688401 cites W2012187456 @default.
- W126688401 cites W2012988898 @default.
- W126688401 cites W2017661147 @default.
- W126688401 cites W2021106123 @default.
- W126688401 cites W2026963497 @default.
- W126688401 cites W2029084490 @default.
- W126688401 cites W2030270523 @default.
- W126688401 cites W2033195198 @default.
- W126688401 cites W2035946947 @default.
- W126688401 cites W2039331111 @default.
- W126688401 cites W2039745369 @default.
- W126688401 cites W2042859126 @default.
- W126688401 cites W2044362463 @default.
- W126688401 cites W2046697604 @default.
- W126688401 cites W2049907486 @default.
- W126688401 cites W2050049694 @default.
- W126688401 cites W2056464969 @default.
- W126688401 cites W2057443384 @default.
- W126688401 cites W2057932464 @default.
- W126688401 cites W2060989352 @default.
- W126688401 cites W2061056399 @default.
- W126688401 cites W2061885341 @default.
- W126688401 cites W2063173910 @default.
- W126688401 cites W2065022624 @default.
- W126688401 cites W2066035525 @default.
- W126688401 cites W2067075412 @default.
- W126688401 cites W2068877244 @default.
- W126688401 cites W2071835504 @default.
- W126688401 cites W2073537808 @default.
- W126688401 cites W2077936658 @default.
- W126688401 cites W2080075231 @default.
- W126688401 cites W2080375596 @default.
- W126688401 cites W2082427063 @default.
- W126688401 cites W2083866023 @default.
- W126688401 cites W2084125212 @default.
- W126688401 cites W2085698763 @default.
- W126688401 cites W2088423175 @default.
- W126688401 cites W2088766428 @default.
- W126688401 cites W2088866226 @default.
- W126688401 cites W2089135808 @default.
- W126688401 cites W2091269938 @default.
- W126688401 cites W2091776886 @default.
- W126688401 cites W2092747653 @default.
- W126688401 cites W2093827208 @default.
- W126688401 cites W2094837823 @default.
- W126688401 cites W2105473762 @default.
- W126688401 cites W2116544026 @default.
- W126688401 cites W2116869419 @default.
- W126688401 cites W2117229042 @default.
- W126688401 cites W2118298772 @default.
- W126688401 cites W2122700901 @default.
- W126688401 cites W2125801521 @default.
- W126688401 cites W2136171492 @default.
- W126688401 cites W2147168215 @default.
- W126688401 cites W2150397487 @default.