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- W126711757 abstract "We have previously reported that myogenic tone in ophthalmic artery is impaired in obese type-2 diabetic BBZDR/Wor rat. In this study, we delineated the role of endothelium-derived reactive oxygen species (ROS) in the attenuated myogenic response. Ophthalmic arteries were isolated from BBZDR/Wor rats (T2D) with 4–5 months duration of diabetes and the age-matched lean non-diabetic rats (control). Arterial segments were cannulated in an arteriograph and inner diameter was continuously recorded over a range of intraluminal pressures in the presence or absence of different pharmacological agents. Pressure-induced constriction in T2D artery was significantly lower compared to that control in the range of 50–150 mmHg. Dilation to carbachol or bradykinin was significantly lower and L-NAME (non-specific nitric oxide synthase inhibitor)-mediated constriction was higher in T2D artery compared to the control when studied at an intraluminal pressure of 70 mmHg. In the presence of 4-aminoguanidine, myogenic tone T2D artery was comparable to that of control over the pressure range of 50–150 mmHg. Similar results were observed when T3D artery was treated with a scavenger of ROS, N-acetyl cysteine, NADPH oxidase inhibitor apocynin or peroxynitrite scavenger ebselen. These results suggest that peroxynitrite generated from superoxide and NO acts on arterial smooth muscle and antagonizes myogenic tone." @default.
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- W126711757 date "2010-04-01" @default.
- W126711757 modified "2023-10-16" @default.
- W126711757 title "Endothelium‐derived reactive oxygen species impair myogenic tone in type‐2 diabetic rat ophthalmic artery" @default.
- W126711757 doi "https://doi.org/10.1096/fasebj.24.1_supplement.571.4" @default.
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