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- W126714878 abstract "1. Fura-2 imaging was used to measure the effects of glutamate on caffeine-sensitive Ca2+ stores in neurons of the avian cochlear nucleus, n. magnocellularis (NM). 2. On average, 100-mM caffeine stimulated a 250-nM increase in intracellular calcium ion concentration inverted question mark[Ca2+]i inverted question mark in Ca(2+)-free media; 1-mM glutamate significantly attenuated caffeine-stimulated Ca2+ responses. 3. The metabotropic glutamate receptor agonist, ACPD, also inhibited the caffeine-stimulated rise in [Ca2+]i. 4. Glutamate has an important role in regulating Ca2+ stores in NM neurons. Glutamate-deprivation (viz. cochlear removal) results in a rise in [Ca2+]i that may, in part, be the result of release from Ca2+ stores. We hypothesize that Ca(2+)-induced Ca2+ release stores (CICRs) may be involved in deprivation-induced cell death." @default.
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- W126714878 date "1996-07-01" @default.
- W126714878 modified "2023-10-11" @default.
- W126714878 title "Glutamate modulates intracellular Ca2+ stores in brain stem auditory neurons" @default.
- W126714878 doi "https://doi.org/10.1152/jn.1996.76.1.646" @default.
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