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• W126720373 endingPage "782" @default.
• W126720373 startingPage "761" @default.
• W126720373 abstract "1. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor of the helix-loop-helix/PAS family. Many compounds interact with the AhR including xenobiotic (“xeno” = foreign) polycyclic aromatic hydrocarbons (PAH) and dioxins, endogenous ligands, and natural bioactive compounds. The activation of the AhR leads to increased expression of Phase I enzymes at xenobiotic responsive elements (XRE) and production of chemically reactive species known to induce cancer. Conversely, activation of the AhR leads to decreased expression of the tumor-suppressor genes p16 and BRCA-1. 2. Data from both animal and human studies suggest that the persistent activation of the AhR may be a risk factor and promote various types of cancer. In particular, PAH appear to preferentially induce mammary tumors in preclinical models. Natural modulators of the AhR include the phytoalexin resveratrol, the indole compounds indole-3-carbinol (I3C) and its condensation product 3,3′-diindolylmethane (DIM), several flavonoids, and catechins. 3. Data from cell culture and animal studies suggest that at relatively low concentration (∼10 μM), DIM may exert antagonistic protective effects, whereas at higher levels (∼100 μM), it may exert agonistic effects and activate the expression of P450. Animal studies reported that the compound I3C may also promote tumor development. The therapeutic properties of these compounds may be influenced by various factors including cell context, timing of exposure, concentration, and relative binding affinity for the AhR. 4. Both the bioavailability and pharmacokinetics of AhR ligands from phytochemicals may influence the therapeutic values of preventative strategies based on AhR antagonists. 5. Although further investigations are necessary to assess the potential benefits of AhR-based strategies against cancer, it is suggested that several phytochemicals may exert protective effects and reduce the risk of toxicity and cancer through competitive transformation of the AhR." @default.
• W126720373 created "2016-06-24" @default.
• W126720373 creator A5037982277 @default.
• W126720373 creator A5039716341 @default.
• W126720373 creator A5084037167 @default.
• W126720373 date "2010-01-01" @default.
• W126720373 modified "2023-10-14" @default.
• W126720373 title "Aryl Hydrocarbon Receptor-Mediated Carcinogenesis and Modulation by Dietary Xenobiotic and Natural Ligands" @default.
• W126720373 cites W1616015704 @default.
• W126720373 cites W1924670518 @default.
• W126720373 cites W1935479846 @default.
• W126720373 cites W1964422998 @default.
• W126720373 cites W1967557898 @default.
• W126720373 cites W1968906511 @default.
• W126720373 cites W1974048771 @default.
• W126720373 cites W1974571230 @default.
• W126720373 cites W1975114834 @default.
• W126720373 cites W1976182007 @default.
• W126720373 cites W1976381556 @default.
• W126720373 cites W1976777279 @default.
• W126720373 cites W1976846448 @default.
• W126720373 cites W1979162100 @default.
• W126720373 cites W1980537841 @default.
• W126720373 cites W1980708125 @default.
• W126720373 cites W1980998456 @default.
• W126720373 cites W1989305556 @default.
• W126720373 cites W1989986502 @default.
• W126720373 cites W1990735888 @default.
• W126720373 cites W1994174646 @default.
• W126720373 cites W1995780371 @default.
• W126720373 cites W1996721582 @default.
• W126720373 cites W2000423718 @default.
• W126720373 cites W2002568575 @default.
• W126720373 cites W2002597568 @default.
• W126720373 cites W2003480039 @default.
• W126720373 cites W2003606716 @default.
• W126720373 cites W2004612031 @default.
• W126720373 cites W2005404705 @default.
• W126720373 cites W2006183127 @default.
• W126720373 cites W2007185557 @default.
• W126720373 cites W2007601885 @default.
• W126720373 cites W2009671845 @default.
• W126720373 cites W2009781449 @default.
• W126720373 cites W2009809165 @default.
• W126720373 cites W2010771707 @default.
• W126720373 cites W2013346975 @default.
• W126720373 cites W2015078897 @default.
• W126720373 cites W2017229541 @default.
• W126720373 cites W2018951556 @default.
• W126720373 cites W2019388528 @default.
• W126720373 cites W2020909568 @default.
• W126720373 cites W2022154327 @default.
• W126720373 cites W2023439354 @default.
• W126720373 cites W2026959257 @default.
• W126720373 cites W2026978748 @default.
• W126720373 cites W2029275372 @default.
• W126720373 cites W2029521910 @default.
• W126720373 cites W2029588268 @default.
• W126720373 cites W2035706540 @default.
• W126720373 cites W2035719812 @default.
• W126720373 cites W2037482981 @default.
• W126720373 cites W2039389146 @default.
• W126720373 cites W2039830969 @default.
• W126720373 cites W2041550216 @default.
• W126720373 cites W2041776945 @default.
• W126720373 cites W2043416509 @default.
• W126720373 cites W2050581983 @default.
• W126720373 cites W2060236190 @default.
• W126720373 cites W2060645387 @default.
• W126720373 cites W2060760516 @default.
• W126720373 cites W2063344487 @default.
• W126720373 cites W2066254714 @default.
• W126720373 cites W2067227701 @default.
• W126720373 cites W2071813734 @default.
• W126720373 cites W2075058621 @default.
• W126720373 cites W2076366012 @default.
• W126720373 cites W2082770850 @default.
• W126720373 cites W2084185538 @default.
• W126720373 cites W2084200591 @default.
• W126720373 cites W2084284247 @default.
• W126720373 cites W2084311588 @default.
• W126720373 cites W2085294848 @default.
• W126720373 cites W2087250942 @default.
• W126720373 cites W2087590680 @default.
• W126720373 cites W2087871494 @default.
• W126720373 cites W2088501123 @default.
• W126720373 cites W2089362925 @default.
• W126720373 cites W2089804471 @default.
• W126720373 cites W2091726431 @default.
• W126720373 cites W2092081465 @default.
• W126720373 cites W2093017044 @default.
• W126720373 cites W2094348831 @default.
• W126720373 cites W2094451152 @default.
• W126720373 cites W2095784554 @default.
• W126720373 cites W2095923098 @default.
• W126720373 cites W2097796945 @default.
• W126720373 cites W2099725620 @default.
• W126720373 cites W2100269181 @default.

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