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- W126878462 abstract "OBJECTIVE: To present two cases of tardive dyskinesia (TD) markedly improved with administration of zolpidem, and to discuss potential use of zolpidem in TD. BACKGROUND: TD is a group of delayed-onset, iatrogenic movement disorders caused by dopamine-receptor blocking agents. TD frequently persists after eliminating offending drugs, and is often resistant to pharmacological treatment. Zolpidem is a nonbenzodiazepine-related hypnotic drug that binds to the omega site of the GABA-benzodiazepine receptor complex found in high density in basal ganglia. Zolpidem was previously reported to be effective in a variety of movement disorders including Parkinson9s disease, myoclonus-dystonia syndrome, primary dystonia, progressive supranuclear palsy, and ataxia. One animal study concluded that zolpidem exhibits neuroprotective and anti-oxidant qualities and therefore can prevent and treat TD.There were no human studies or reports of zolpidem effectiveness in TD. DESIGN/METHODS: Patients with TD who reported improvement of the symptoms with zolpidem were identified from our video database from 9/2006 through 10/2012. Patients9 videos before and after administration of a single dose of zolpidem were compared. RESULTS: Patient 1. 67 year-old woman was treated with neuroleptics for multiple personality disorder with psychosis and developed TD with oro-bucco-lingual stereotypy, craniocervical dystonia, dystonic respiratory dysregulation, resistant to conventional medications. All symptoms markedly improved after a single dose of 15 mg of zolpidem. Patient 2. 25 year-old woman with recurrent psychotic episodes treated with neuroleptics, developed generalized TD, tardive craniocervical dystonia and severe akathisia, unresponsive to tetrabenazine. All symptoms dramatically improved after 10 mg of zolpidem. Both patients continued having good benefit from zolpidem administered a few times daily without side effects of drowsiness. CONCLUSIONS: Zolpidem can be safe and effective alternative treatment of TD with and without akathisia, resistant to other medications. A placebo-controlled study is needed to further investigate the effectiveness of zolpidem in TD. Disclosure: Dr. Waln has nothing to disclose. Dr. Jankovic has received personal compensation for activities with Allergan, Inc., Chelsea Therapeutics, EMD Serono, Merz Pharmaceuticals, Lundbeck, and Teva Neuroscience as a consultant. Dr. Jankovic has received personal compensation in an editorial capacity for Medlink: Neurology in Clinical Practice. Dr. Jankovic has received research support from Allergan, Inc, Allon Therapeutics, Ceregene, Inc, Chelsea Therapeutics, Diana Helis Henry Medical Research Foundation, EMD Serono, Huntington9s Disease Society of America, Huntington Study Group, Impax Pharmaceuticals, and Ipsen Limited." @default.
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- W126878462 date "2013-02-12" @default.
- W126878462 modified "2023-09-28" @default.
- W126878462 title "Zolpidem Improves Tardive Dyskinesia with and without Akathisia (P07.205)" @default.
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